PDGFRA
Gene Ontology Biological Process
- Leydig cell differentiation [IMP]
- adrenal gland development [IGI]
- anatomical structure morphogenesis [IMP]
- cardiac myofibril assembly [IGI]
- cell chemotaxis [IMP, ISO]
- cell migration [IMP]
- cellular response to amino acid stimulus [IDA]
- cellular response to platelet-derived growth factor stimulus [IDA]
- embryonic cranial skeleton morphogenesis [IMP]
- embryonic digestive tract morphogenesis [IMP]
- estrogen metabolic process [IGI]
- extracellular matrix organization [IMP]
- face morphogenesis [IMP]
- female gonad development [IGI]
- hematopoietic progenitor cell differentiation [IMP]
- in utero embryonic development [IMP]
- lung development [IMP]
- luteinization [IGI, IMP]
- male genitalia development [IMP]
- metanephric glomerular capillary formation [IGI]
- negative regulation of platelet activation [ISO]
- odontogenesis of dentin-containing tooth [IMP]
- organ morphogenesis [IMP]
- palate development [IMP]
- peptidyl-tyrosine phosphorylation [IDA, ISO]
- phosphatidylinositol-mediated signaling [ISO]
- platelet aggregation [ISO]
- platelet-derived growth factor receptor signaling pathway [IMP, ISO]
- platelet-derived growth factor receptor-alpha signaling pathway [IDA, ISO]
- positive regulation of DNA replication [ISO]
- positive regulation of ERK1 and ERK2 cascade [ISO]
- positive regulation of cell migration [ISO]
- positive regulation of cell proliferation [ISO]
- positive regulation of cell proliferation by VEGF-activated platelet derived growth factor receptor signaling pathway [ISO]
- positive regulation of cytosolic calcium ion concentration [ISO]
- positive regulation of fibroblast proliferation [ISO]
- positive regulation of phosphatidylinositol 3-kinase activity [ISO]
- positive regulation of phospholipase C activity [ISO]
- protein autophosphorylation [IDA, ISO]
- regulation of chemotaxis [ISO]
- regulation of mesenchymal stem cell differentiation [ISO]
- retina vasculature development in camera-type eye [IGI]
- signal transduction involved in regulation of gene expression [IDA]
- skeletal system morphogenesis [IMP]
- wound healing [IMP]
Gene Ontology Molecular Function- phosphatidylinositol 3-kinase binding [ISO]
- platelet-derived growth factor alpha-receptor activity [IDA, ISO]
- platelet-derived growth factor binding [IDA, ISO, TAS]
- platelet-derived growth factor receptor binding [ISO]
- protein complex binding [IDA]
- protein homodimerization activity [ISO]
- transmembrane receptor protein tyrosine kinase activity [ISO]
- vascular endothelial growth factor binding [ISO]
- vascular endothelial growth factor-activated receptor activity [ISO]
- phosphatidylinositol 3-kinase binding [ISO]
- platelet-derived growth factor alpha-receptor activity [IDA, ISO]
- platelet-derived growth factor binding [IDA, ISO, TAS]
- platelet-derived growth factor receptor binding [ISO]
- protein complex binding [IDA]
- protein homodimerization activity [ISO]
- transmembrane receptor protein tyrosine kinase activity [ISO]
- vascular endothelial growth factor binding [ISO]
- vascular endothelial growth factor-activated receptor activity [ISO]
Gene Ontology Cellular Component
PRMT5
Gene Ontology Biological Process
- circadian regulation of gene expression [IMP]
- endothelial cell activation [ISO]
- histone H4-R3 methylation [IMP]
- histone arginine methylation [IBA]
- negative regulation of cell differentiation [ISO]
- negative regulation of transcription from RNA polymerase II promoter [IMP]
- peptidyl-arginine N-methylation [ISO]
- peptidyl-arginine methylation [ISO]
- peptidyl-arginine methylation, to symmetrical-dimethyl arginine [IBA, ISO]
- positive regulation of oligodendrocyte differentiation [ISO]
- protein methylation [ISO]
- regulation of DNA methylation [ISO]
- regulation of ERK1 and ERK2 cascade [ISO]
- spliceosomal snRNP assembly [ISO]
Gene Ontology Molecular Function- chromatin binding [IMP]
- core promoter sequence-specific DNA binding [IDA]
- histone-arginine N-methyltransferase activity [IBA]
- methyltransferase activity [ISO]
- protein binding [IPI]
- protein complex binding [ISO]
- protein-arginine omega-N symmetric methyltransferase activity [ISO]
- ribonucleoprotein complex binding [ISO]
- transcription corepressor activity [IMP]
- chromatin binding [IMP]
- core promoter sequence-specific DNA binding [IDA]
- histone-arginine N-methyltransferase activity [IBA]
- methyltransferase activity [ISO]
- protein binding [IPI]
- protein complex binding [ISO]
- protein-arginine omega-N symmetric methyltransferase activity [ISO]
- ribonucleoprotein complex binding [ISO]
- transcription corepressor activity [IMP]
Affinity Capture-Western
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner identified by Western blot with a specific polyclonal antibody or second epitope tag. This category is also used if an interacting protein is visualized directly by dye stain or radioactivity. Note that this differs from any co-purification experiment involving affinity capture in that the co-purification experiment involves at least one extra purification step to get rid of potential contaminating proteins.
Publication
Loss of PRMT5 Promotes PDGFRα Degradation during Oligodendrocyte Differentiation and Myelination.
The oligodendrocyte lineage is responsible for myelination of the central nervous system. Post-translational modifications are known to regulate oligodendrocyte precursor cell (OPC) differentiation into mature myelinating oligodendrocytes. The role of arginine methylation during oligodendrocyte differentiation and myelination is still poorly understood. We generated mice depleted of PRMT5 in OPCs using Olig2-Cre, and these mice developed severe hypomyelination and died at ... [more]
Throughput
- Low Throughput
Related interactions
| Interaction | Experimental Evidence Code | Dataset | Throughput | Score | Curated By | Notes |
|---|---|---|---|---|---|---|
| PRMT5 PDGFRA | Affinity Capture-Western Affinity Capture-Western An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner identified by Western blot with a specific polyclonal antibody or second epitope tag. This category is also used if an interacting protein is visualized directly by dye stain or radioactivity. Note that this differs from any co-purification experiment involving affinity capture in that the co-purification experiment involves at least one extra purification step to get rid of potential contaminating proteins. | Low | - | BioGRID | - |
Curated By
- BioGRID