BAIT
NTRK2
RATTRKB1, TRKB1, Tkrb, trk-B, trkB
neurotrophic tyrosine kinase, receptor, type 2
GO Process (44)
GO Function (8)
GO Component (24)
Gene Ontology Biological Process
- aging [IEP]
- brain-derived neurotrophic factor receptor signaling pathway [IDA, IMP, ISO]
- calcium-mediated signaling using intracellular calcium source [ISO]
- cellular response to brain-derived neurotrophic factor stimulus [IEP]
- cellular response to nerve growth factor stimulus [IEP]
- cellular response to tumor necrosis factor [IEP]
- central nervous system neuron development [ISO, ISS]
- cerebral cortex development [ISO, ISS]
- feeding behavior [ISO]
- glutamate secretion [ISO]
- inflammatory response [IEP]
- learning [ISO, ISS]
- long-term memory [IDA]
- long-term synaptic potentiation [ISO]
- mechanoreceptor differentiation [ISO]
- negative regulation of anoikis [ISO]
- negative regulation of neuron apoptotic process [IMP]
- neuromuscular junction development [ISO]
- neuron differentiation [ISO, ISS]
- neuron migration [ISO, ISS]
- neurotrophin signaling pathway [IDA, IMP, ISO]
- oligodendrocyte differentiation [ISO]
- peptidyl-tyrosine phosphorylation [IMP, ISO]
- peripheral nervous system neuron development [ISO]
- positive regulation of MAPK cascade [IMP]
- positive regulation of axonogenesis [IMP]
- positive regulation of cell proliferation [IDA]
- positive regulation of gene expression [ISO, ISS]
- positive regulation of glucocorticoid receptor signaling pathway [IGI]
- positive regulation of neuron projection development [ISO, ISS]
- positive regulation of peptidyl-serine phosphorylation [ISO]
- positive regulation of phosphatidylinositol 3-kinase signaling [IMP]
- positive regulation of synaptic transmission, glutamatergic [IMP]
- protein autophosphorylation [IDA, IMP]
- regulation of MAPK cascade [IDA]
- regulation of Rac GTPase activity [ISO, ISS]
- regulation of dendrite development [IMP]
- regulation of metabolic process [ISO]
- regulation of neurotransmitter secretion [IDA]
- regulation of protein kinase B signaling [ISO]
- response to auditory stimulus [IEP]
- response to light stimulus [IEP]
- retinal rod cell development [ISO]
- vasculogenesis [ISO]
Gene Ontology Molecular Function- brain-derived neurotrophic factor binding [IDA, IMP, ISO]
- brain-derived neurotrophic factor-activated receptor activity [IDA, ISO]
- ephrin receptor binding [IPI]
- neurotrophin binding [IDA, ISO, ISS]
- neurotrophin receptor activity [IDA, IMP]
- protein binding [IPI]
- protein homodimerization activity [IDA]
- transmembrane receptor protein tyrosine kinase activity [IMP]
- brain-derived neurotrophic factor binding [IDA, IMP, ISO]
- brain-derived neurotrophic factor-activated receptor activity [IDA, ISO]
- ephrin receptor binding [IPI]
- neurotrophin binding [IDA, ISO, ISS]
- neurotrophin receptor activity [IDA, IMP]
- protein binding [IPI]
- protein homodimerization activity [IDA]
- transmembrane receptor protein tyrosine kinase activity [IMP]
Gene Ontology Cellular Component
- Golgi membrane [TAS]
- axon [IDA]
- axon terminus [IDA]
- cell [ISO]
- cell surface [IDA]
- cytoplasm [IDA]
- cytosol [ISO]
- dendrite [IDA]
- dendritic spine [IDA]
- endosome [ISO]
- excitatory synapse [IDA]
- growth cone [IDA]
- integral component of plasma membrane [IDA, ISO]
- intracellular [ISO]
- neuronal cell body [IDA]
- neuronal postsynaptic density [ISO]
- perikaryon [IDA]
- plasma membrane [IDA, ISO, TAS]
- postsynaptic density [IDA]
- postsynaptic membrane [ISO]
- presynaptic active zone [IDA]
- receptor complex [ISO]
- rough endoplasmic reticulum [IDA]
- terminal bouton [ISO]
Rattus norvegicus
PREY
BDNF
brain-derived neurotrophic factor
GO Process (68)
GO Function (2)
GO Component (13)
Gene Ontology Biological Process
- axon extension [ISO]
- axon guidance [ISO]
- axon target recognition [ISO]
- behavioral fear response [ISO]
- cellular response to nerve growth factor stimulus [IEP]
- cellular response to norepinephrine stimulus [IEP]
- cellular response to tumor necrosis factor [IEP]
- chronic inflammatory response [IEP]
- cognition [IEP]
- dendrite development [ISO]
- dendrite extension [ISO]
- fear response [ISO]
- feeding behavior [ISO]
- gamma-aminobutyric acid signaling pathway [ISO]
- glutamate secretion [ISO]
- inner ear development [ISO]
- learning [IMP]
- learning or memory [ISO]
- mechanoreceptor differentiation [ISO]
- mitochondrial electron transport, NADH to ubiquinone [IMP]
- negative regulation of apoptotic process [ISO]
- negative regulation of cell death [ISO]
- negative regulation of neuroblast proliferation [ISO]
- negative regulation of neuron apoptotic process [IBA, ISO]
- negative regulation of neuron death [IMP]
- negative regulation of striated muscle tissue development [IMP]
- negative regulation of synaptic transmission, GABAergic [ISO]
- nerve development [ISO]
- nervous system development [IDA]
- neuron differentiation [TAS]
- neuron projection extension [IDA]
- neuron recognition [ISO]
- positive regulation of glucocorticoid receptor signaling pathway [IDA]
- positive regulation of long-term neuronal synaptic plasticity [IMP]
- positive regulation of neuron differentiation [ISO]
- positive regulation of peptidyl-serine phosphorylation [IGI, ISO]
- positive regulation of sequence-specific DNA binding transcription factor activity [IDA]
- positive regulation of synapse assembly [ISO]
- regulation of axon extension [IMP]
- regulation of excitatory postsynaptic membrane potential [IMP]
- regulation of inhibitory postsynaptic membrane potential [ISO]
- regulation of long-term neuronal synaptic plasticity [IDA]
- regulation of metabolic process [ISO]
- regulation of neuron apoptotic process [ISO]
- regulation of retinal cell programmed cell death [ISO]
- regulation of short-term neuronal synaptic plasticity [IDA]
- regulation of synaptic plasticity [ISO]
- response to L-glutamate [IEP]
- response to activity [IEP]
- response to anesthetic [IEP]
- response to auditory stimulus [IEP]
- response to drug [IEP, ISO]
- response to electrical stimulus [IEP]
- response to fluoxetine [IEP]
- response to food [IEP]
- response to hormone [IEP]
- response to hyperoxia [IEP]
- response to hypoxia [IEP]
- response to light intensity [IEP]
- response to light stimulus [IEP]
- response to nerve growth factor [IEP]
- response to nutrient levels [IEP]
- response to potassium ion [IEP]
- response to tumor necrosis factor [IEP]
- response to vitamin A [IEP]
- taste bud development [ISO]
- transmembrane receptor protein tyrosine kinase signaling pathway [IBA]
- ureteric bud development [ISO]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Rattus norvegicus
Affinity Capture-Western
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner identified by Western blot with a specific polyclonal antibody or second epitope tag. This category is also used if an interacting protein is visualized directly by dye stain or radioactivity. Note that this differs from any co-purification experiment involving affinity capture in that the co-purification experiment involves at least one extra purification step to get rid of potential contaminating proteins.
Publication
Prenatal Cocaine Exposure Upregulates BDNF-TrkB Signaling.
Prenatal cocaine exposure causes profound changes in neurobehavior as well as synaptic function and structure with compromised glutamatergic transmission. Since synaptic health and glutamatergic activity are tightly regulated by brain-derived neurotrophic factor (BDNF) signaling through its cognate tyrosine receptor kinase B (TrkB), we hypothesized that prenatal cocaine exposure alters BDNF-TrkB signaling during brain development. Here we show prenatal cocaine exposure ... [more]
PLoS ONE Aug. 06, 2016; 11(8);e0160585 [Pubmed: 27494324]
Throughput
- Low Throughput
Curated By
- BioGRID