BAIT
NGFR
LNGFR, RNNGFRR, Tnfrsf16, p75, p75NTR
nerve growth factor receptor
GO Process (37)
GO Function (9)
GO Component (17)
Gene Ontology Biological Process
- axon guidance [ISO]
- cellular response to oxidative stress [IMP]
- central nervous system development [ISO]
- circadian regulation of gene expression [ISO, ISS]
- detection of temperature stimulus [ISO]
- glucose homeostasis [ISO, ISS]
- hair follicle morphogenesis [ISO]
- intracellular protein transport [ISO, ISS]
- negative regulation of cell death [IDA]
- negative regulation of fibroblast growth factor receptor signaling pathway [ISO]
- negative regulation of hair follicle development [ISO]
- negative regulation of mitochondrial depolarization [IMP]
- negative regulation of neuron apoptotic process [IMP]
- negative regulation of neuron projection development [IDA]
- nerve development [ISO]
- positive regulation of MAPK cascade [IDA]
- positive regulation of Rho protein signal transduction [IDA]
- positive regulation of apoptotic process [IMP]
- positive regulation of apoptotic signaling pathway [ISO]
- positive regulation of cell death [IDA]
- positive regulation of fibroblast proliferation [ISO]
- positive regulation of myelination [IMP]
- positive regulation of neuron death [IDA]
- positive regulation of odontogenesis of dentin-containing tooth [ISO]
- positive regulation of protein kinase B signaling [IDA]
- positive regulation of synaptic transmission, cholinergic [IMP]
- positive regulation of synaptic transmission, glutamatergic [IMP]
- programmed cell death [ISO]
- regulation of gene expression [ISO]
- regulation of glucose import in response to insulin stimulus [ISO, ISS]
- regulation of reactive oxygen species metabolic process [IMP]
- response to lipopolysaccharide [IEP]
- response to wounding [IMP]
- sensory perception of pain [IMP]
- signal transduction [IDA, ISO]
- skeletal muscle cell differentiation [IEP]
- skin development [ISO]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
- Golgi apparatus [IDA]
- cell [ISO]
- cell surface [ISO]
- clathrin-coated endocytic vesicle [IDA]
- coated vesicle [IDA]
- cytoplasm [IDA, ISO]
- dendrite membrane [IDA]
- external side of plasma membrane [IDA]
- intracellular [ISO]
- membrane raft [IDA]
- neuronal cell body membrane [IDA]
- neuronal postsynaptic density [ISO]
- nuclear envelope [IDA]
- nucleus [IDA]
- perikaryon [IDA]
- plasma membrane [IDA, ISO, TAS]
- rough endoplasmic reticulum [IDA]
Rattus norvegicus
PREY
TRAF6
TNF receptor-associated factor 6, E3 ubiquitin protein ligase
GO Process (44)
GO Function (11)
GO Component (12)
Gene Ontology Biological Process
- I-kappaB kinase/NF-kappaB signaling [ISO]
- JNK cascade [IMP]
- T cell receptor signaling pathway [ISO]
- T-helper 1 type immune response [ISO]
- activation of NF-kappaB-inducing kinase activity [ISO]
- activation of protein kinase activity [ISO]
- antigen processing and presentation of exogenous peptide antigen via MHC class II [ISO]
- bone remodeling [ISO]
- bone resorption [ISO]
- cell development [ISO]
- cellular response to lipopolysaccharide [ISO]
- cytokine-mediated signaling pathway [IMP]
- immune response [ISO]
- interleukin-1-mediated signaling pathway [IMP, ISO]
- myeloid dendritic cell differentiation [ISO]
- negative regulation of transcription from RNA polymerase II promoter [ISO]
- negative regulation of transcription, DNA-templated [ISO]
- neural tube closure [ISO]
- odontogenesis of dentin-containing tooth [ISO]
- organ morphogenesis [ISO]
- ossification [ISO]
- osteoclast differentiation [ISO]
- positive regulation of I-kappaB kinase/NF-kappaB signaling [ISO, ISS]
- positive regulation of JUN kinase activity [ISO]
- positive regulation of NF-kappaB transcription factor activity [ISO, ISS]
- positive regulation of T cell cytokine production [ISO]
- positive regulation of T cell proliferation [ISO]
- positive regulation of interleukin-12 biosynthetic process [ISO]
- positive regulation of interleukin-2 production [ISO]
- positive regulation of interleukin-6 biosynthetic process [ISO]
- positive regulation of lipopolysaccharide-mediated signaling pathway [ISO]
- positive regulation of osteoclast differentiation [ISO]
- positive regulation of sequence-specific DNA binding transcription factor activity [ISO]
- positive regulation of smooth muscle cell proliferation [IMP]
- positive regulation of transcription from RNA polymerase II promoter [ISO]
- positive regulation of transcription regulatory region DNA binding [ISO]
- protein K63-linked ubiquitination [ISO, ISS]
- protein autoubiquitination [ISO]
- protein complex assembly [IMP]
- protein polyubiquitination [ISO]
- protein ubiquitination [ISO]
- regulation of immunoglobulin secretion [ISO]
- response to interleukin-1 [ISO]
- signal transduction [ISO]
Gene Ontology Molecular Function- histone deacetylase binding [ISO]
- mitogen-activated protein kinase kinase kinase binding [ISO]
- protein N-terminus binding [ISO]
- protein kinase B binding [ISO]
- protein kinase binding [ISO]
- thioesterase binding [ISO]
- tumor necrosis factor receptor binding [ISO]
- ubiquitin conjugating enzyme binding [ISO]
- ubiquitin protein ligase activity [ISO]
- ubiquitin protein ligase binding [ISO]
- ubiquitin-protein transferase activity [ISO, ISS]
- histone deacetylase binding [ISO]
- mitogen-activated protein kinase kinase kinase binding [ISO]
- protein N-terminus binding [ISO]
- protein kinase B binding [ISO]
- protein kinase binding [ISO]
- thioesterase binding [ISO]
- tumor necrosis factor receptor binding [ISO]
- ubiquitin conjugating enzyme binding [ISO]
- ubiquitin protein ligase activity [ISO]
- ubiquitin protein ligase binding [ISO]
- ubiquitin-protein transferase activity [ISO, ISS]
Gene Ontology Cellular Component
Rattus norvegicus
Affinity Capture-Western
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner identified by Western blot with a specific polyclonal antibody or second epitope tag. This category is also used if an interacting protein is visualized directly by dye stain or radioactivity. Note that this differs from any co-purification experiment involving affinity capture in that the co-purification experiment involves at least one extra purification step to get rid of potential contaminating proteins.
Publication
Prenatal Cocaine Exposure Upregulates BDNF-TrkB Signaling.
Prenatal cocaine exposure causes profound changes in neurobehavior as well as synaptic function and structure with compromised glutamatergic transmission. Since synaptic health and glutamatergic activity are tightly regulated by brain-derived neurotrophic factor (BDNF) signaling through its cognate tyrosine receptor kinase B (TrkB), we hypothesized that prenatal cocaine exposure alters BDNF-TrkB signaling during brain development. Here we show prenatal cocaine exposure ... [more]
PLoS ONE Aug. 06, 2016; 11(8);e0160585 [Pubmed: 27494324]
Throughput
- Low Throughput
Curated By
- BioGRID