TNC
Gene Ontology Biological Process
- bud outgrowth involved in lung branching [IMP]
- cellular response to prostaglandin D stimulus [IEP]
- cellular response to retinoic acid [IEP]
- cellular response to vitamin D [IEP]
- mesenchymal-epithelial cell signaling involved in prostate gland development [ISO]
- negative regulation of cell adhesion [IDA]
- neuromuscular junction development [ISO]
- neuron projection development [IMP]
- odontogenesis of dentin-containing tooth [IEP]
- osteoblast differentiation [ISO]
- peripheral nervous system axon regeneration [ISO]
- positive regulation of cell proliferation [ISO]
- positive regulation of gene expression [ISO]
- prostate gland epithelium morphogenesis [ISO]
- response to ethanol [IEP]
- response to fibroblast growth factor [IEP]
- response to mechanical stimulus [IEP]
- response to wounding [ISO]
- wound healing [IEP]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
PTPRZ1
Gene Ontology Biological Process
- axonal fasciculation [IDA]
- axonogenesis [ISO]
- brain development [IEP]
- hematopoietic progenitor cell differentiation [ISO]
- hippocampus development [IEP]
- learning or memory [ISO, ISS]
- negative regulation of cell proliferation [IMP]
- negative regulation of cell-substrate adhesion [IDA]
- negative regulation of dendrite development [IDA]
- neuron development [IEP]
- oligodendrocyte differentiation [IEP, ISO, ISS]
- peptidyl-tyrosine dephosphorylation [IDA, ISO, ISS]
- positive regulation of Schwann cell migration [IMP]
- positive regulation of cell migration [IDA]
- positive regulation of dendrite development [IDA]
- positive regulation of fibroblast proliferation [IDA]
- positive regulation of neuron death [IDA]
- positive regulation of neuron migration [IMP]
- positive regulation of neuron projection development [IMP]
- positive regulation of peptidyl-tyrosine phosphorylation [IDA]
- protein dephosphorylation [IDA]
- regulation of dendrite morphogenesis [IMP]
- regulation of oligodendrocyte progenitor proliferation [ISO, ISS]
- visual learning [IEP]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Reconstituted Complex
An interaction is inferred between proteins in vitro. This can include proteins in recombinant form or proteins isolated directly from cells with recombinant or purified bait. For example, GST pull-down assays where a GST-tagged protein is first isolated and then used to fish interactors from cell lysates are considered reconstituted complexes (e.g. PUBMED: 14657240, Fig. 4A or PUBMED: 14761940, Fig. 5). This can also include gel-shifts, surface plasmon resonance, isothermal titration calorimetry (ITC) and bio-layer interferometry (BLI) experiments. The bait-hit directionality may not be clear for 2 interacting proteins. In these cases the directionality is up to the discretion of the curator.
Publication
The fibrinogen-like globe of tenascin-C mediates its interactions with neurocan and phosphacan/protein-tyrosine phosphatase-zeta/beta.
Two nervous tissue-specific chondroitin sulfate proteoglycans, neurocan and phosphacan (the extracellular domain of protein-tyrosine phosphatase-zeta/beta), are high-affinity ligands of tenascin-C. Using portions of tenascin-C expressed as recombinant proteins in human fibrosarcoma cells, we have demonstrated both by direct radioligand binding assays and inhibition studies that phosphacan binding is retained in all deletion variants except those lacking the fibrinogen-like globe and ... [more]
Throughput
- Low Throughput
Related interactions
| Interaction | Experimental Evidence Code | Dataset | Throughput | Score | Curated By | Notes |
|---|---|---|---|---|---|---|
| TNC PTPRZ1 | Reconstituted Complex Reconstituted Complex An interaction is inferred between proteins in vitro. This can include proteins in recombinant form or proteins isolated directly from cells with recombinant or purified bait. For example, GST pull-down assays where a GST-tagged protein is first isolated and then used to fish interactors from cell lysates are considered reconstituted complexes (e.g. PUBMED: 14657240, Fig. 4A or PUBMED: 14761940, Fig. 5). This can also include gel-shifts, surface plasmon resonance, isothermal titration calorimetry (ITC) and bio-layer interferometry (BLI) experiments. The bait-hit directionality may not be clear for 2 interacting proteins. In these cases the directionality is up to the discretion of the curator. | Low | - | BioGRID | - |
Curated By
- BioGRID