An interaction is inferred from the identification of two or more protein subunits in a purified protein complex, as obtained by classical biochemical fractionation or affinity purification and one or more additional fractionation steps.

Publication

Receptor tyrosine phosphatase beta (RPTPbeta) activity and signaling are attenuated by glycosylation and subsequent cell surface galectin-1 binding.

Abbott KL, Matthews RT, Pierce M

O-Mannosyl-linked glycosylation is abundant within the central nervous system, yet very few glycoproteins with this glycan modification have been identified. Congenital diseases with significant neurological defects arise from inactivating mutations found within the glycosyltransferases that act early in the O-mannosyl glycosylation pathway. The N-acetylglucosaminyltransferase known as GnT-Vb or -IX is highly expressed in brain and branches O-mannosyl-linked glycans. Our results ... [more]

J. Biol. Chem. Nov. 28, 2008; 283(48);33026-35 [Pubmed: 18838383]

Throughput

Low Throughput

Curated By

BioGRID

Interaction Summary

PTPRZ1

Gene Ontology Biological Process

Gene Ontology Molecular Function

protein binding [IPI]protein tyrosine phosphatase activity [ISS]transmembrane receptor protein tyrosine phosphatase activity [TAS]

Gene Ontology Cellular Component