PTPRO
Gene Ontology Biological Process
- axon guidance [IMP]
- cell morphogenesis [IMP]
- glomerular visceral epithelial cell differentiation [IMP]
- glomerulus development [ISO]
- lamellipodium assembly [IMP]
- monocyte chemotaxis [ISO]
- negative regulation of canonical Wnt signaling pathway [IDA]
- negative regulation of glomerular filtration [ISO]
- peptidyl-tyrosine dephosphorylation [IDA, ISO]
- regulation of glomerular filtration [IMP]
- slit diaphragm assembly [IMP]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
PXN
Gene Ontology Biological Process
- activation of MAPK activity [IDA]
- branching morphogenesis of an epithelial tube [IDA]
- cellular component movement [IMP]
- cytoskeleton organization [IMP]
- focal adhesion assembly [IDA]
- growth hormone receptor signaling pathway [ISO]
- integrin-mediated signaling pathway [IMP, TAS]
- lamellipodium assembly [IDA]
- peptidyl-tyrosine phosphorylation [IDA]
- positive regulation of protein kinase activity [IMP]
- regulation of cell shape [IMP]
- substrate adhesion-dependent cell spreading [IMP]
- transforming growth factor beta receptor signaling pathway [IDA, ISO]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Biochemical Activity (Dephosphorylation)
An interaction is inferred from the biochemical effect of one protein upon another, for example, GTP-GDP exchange activity or phosphorylation of a substrate by a kinase. The bait protein executes the activity on the substrate hit protein. A Modification value is recorded for interactions of this type with the possible values Phosphorylation, Ubiquitination, Sumoylation, Dephosphorylation, Methylation, Prenylation, Acetylation, Deubiquitination, Proteolytic Processing, Glucosylation, Nedd(Rub1)ylation, Deacetylation, No Modification, Demethylation.
Publication
Protein tyrosine phosphatase phi regulates paxillin tyrosine phosphorylation and mediates colony-stimulating factor 1-induced morphological changes in macrophages.
Removal of colony-stimulating factor 1 (CSF-1) causes macrophages to round up and to increase their expression of protein tyrosine phosphatase phi (PTP phi). This is accompanied by the disruption of focal complexes and the formation of ruffles. Here we have overexpressed wild-type (WT) PTP phi and a phosphatase-inactive (C325S) mutant in a macrophage cell line in the presence and absence ... [more]
Throughput
- Low Throughput
Related interactions
| Interaction | Experimental Evidence Code | Dataset | Throughput | Score | Curated By | Notes |
|---|---|---|---|---|---|---|
| PTPRO PXN | Affinity Capture-Western Affinity Capture-Western An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner identified by Western blot with a specific polyclonal antibody or second epitope tag. This category is also used if an interacting protein is visualized directly by dye stain or radioactivity. Note that this differs from any co-purification experiment involving affinity capture in that the co-purification experiment involves at least one extra purification step to get rid of potential contaminating proteins. | Low | - | BioGRID | - | |
| PXN PTPRO | Far Western Far Western An interaction is detected between a protein immobilized on a membrane and a purified protein probe. | Low | - | BioGRID | - | |
| PTPRO PXN | Reconstituted Complex Reconstituted Complex An interaction is detected between purified proteins in vitro. | Low | - | BioGRID | - |
Curated By
- BioGRID