An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods.

Publication

Histone-binding of DPF2 mediates its repressive role in myeloid differentiation.

Huber FM, Greenblatt SM, Davenport AM, Martinez C, Xu Y, Vu LP, Nimer SD, Hoelz A

Double plant homeodomain finger 2 (DPF2) is a highly evolutionarily conserved member of the d4 protein family that is ubiquitously expressed in human tissues and was recently shown to inhibit the myeloid differentiation of hematopoietic stem/progenitor and acute myelogenous leukemia cells. Here, we present the crystal structure of the tandem plant homeodomain finger domain of human DPF2 at 1.6-A resolution. ... [more]

Proc. Natl. Acad. Sci. U.S.A. Dec. 06, 2016; 114(23);6016-6021 [Pubmed: 28533407]

Throughput

High Throughput

Curated By

BioGRID

Interaction Summary

DPF2

Gene Ontology Biological Process

Gene Ontology Molecular Function

RNA polymerase II core promoter proximal region sequence-specific DNA binding [IDA]

Gene Ontology Cellular Component

LRRC59