BAIT
ERBB4
Her4, c-erbB-4, AC167658.1
v-erb-a erythroblastic leukemia viral oncogene homolog 4 (avian)
GO Process (33)
GO Function (6)
GO Component (9)
Gene Ontology Biological Process
- cardiac muscle tissue regeneration [IMP]
- cell fate commitment [IDA]
- cell migration [ISO]
- central nervous system morphogenesis [IMP]
- embryonic pattern specification [IMP]
- heart development [IMP]
- lactation [IMP, ISO]
- mammary gland alveolus development [IMP]
- mammary gland epithelial cell differentiation [IMP]
- mitochondrial fragmentation involved in apoptotic process [ISO]
- negative regulation of apoptotic process [ISO]
- negative regulation of cell proliferation [ISO]
- negative regulation of muscle cell apoptotic process [ISO]
- nervous system development [IMP]
- neural crest cell migration [IMP]
- olfactory bulb interneuron differentiation [IMP]
- peptidyl-tyrosine phosphorylation [ISO]
- positive regulation of ERK1 and ERK2 cascade [ISO]
- positive regulation of STAT protein import into nucleus [IMP, ISO]
- positive regulation of cardiac muscle cell proliferation [IMP]
- positive regulation of cell migration [ISO]
- positive regulation of cell proliferation [ISO]
- positive regulation of epithelial cell proliferation [ISO]
- positive regulation of glucose import [ISO]
- positive regulation of synaptic transmission, GABAergic [ISO]
- positive regulation of transcription, DNA-templated [IMP, ISO]
- positive regulation of tyrosine phosphorylation of Stat5 protein [IMP, ISO]
- protein autophosphorylation [ISO]
- regulation of cell migration [IMP]
- signal transduction [ISO]
- surfactant homeostasis [ISO]
- synapse maturation [ISO]
- transmembrane receptor protein tyrosine kinase signaling pathway [ISO]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Mus musculus
PREY
MAGI2
AIP-1, Acvri1, Acvrinp1, Acvrip1, Magi-2, S-SCAM, mKIAA0705
membrane associated guanylate kinase, WW and PDZ domain containing 2
GO Process (15)
GO Function (9)
GO Component (11)
Gene Ontology Biological Process
- SMAD protein signal transduction [IDA]
- cellular response to nerve growth factor stimulus [ISO]
- cytoplasmic transport [ISO]
- mitotic cell cycle arrest [ISO]
- negative regulation of activin receptor signaling pathway [IDA]
- negative regulation of cell migration [ISO]
- negative regulation of cell proliferation [ISO]
- negative regulation of protein kinase B signaling [ISO]
- nerve growth factor signaling pathway [ISO]
- positive regulation of neuron projection development [ISO]
- positive regulation of phosphoprotein phosphatase activity [ISO]
- positive regulation of receptor internalization [ISO]
- protein heterooligomerization [ISO]
- receptor clustering [ISO]
- signal transduction [IPI]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Mus musculus
Two-hybrid
Bait protein expressed as a DNA binding domain (DBD) fusion and prey expressed as a transcriptional activation domain (TAD) fusion and interaction measured by reporter gene activation.
Publication
Molecular dissection of NRG1-ERBB4 signaling implicates PTPRZ1 as a potential schizophrenia susceptibility gene.
Neuregulin and the neuregulin receptor ERBB4 have been genetically and functionally implicated in schizophrenia. In this study, we used the yeast two-hybrid system to identify proteins that interact with ERBB4, to identify genes and pathways that might contribute to schizophrenia susceptibility. We identified the MAGI scaffolding proteins as ERBB4-binding proteins. After validating the interaction of MAGI proteins with ERBB4 in ... [more]
Mol. Psychiatry Feb. 01, 2008; 13(2);162-72 [Pubmed: 17579610]
Throughput
- Low Throughput
Curated By
- BioGRID