BAIT
TRIM11
BIA1, RNF92
tripartite motif containing 11
GO Process (5)
GO Function (1)
GO Component (1)
Gene Ontology Biological Process
Gene Ontology Molecular Function
Homo sapiens
PREY
MARK1
MARK, Par-1c, Par1c
MAP/microtubule affinity-regulating kinase 1
GO Process (4)
GO Function (7)
GO Component (4)
Gene Ontology Biological Process
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
Affinity Capture-MS
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods.
Publication
TRIM11 activates the proteasome and promotes overall protein degradation by regulating USP14.
The proteasome is a complex protease critical for protein quality control and cell regulation, and its dysfunction is associated with cancer and other diseases. However, the mechanisms that control proteasome activity in normal and malignant cells remain unclear. Here we report that TRIM11 enhances degradation of aberrant and normal regulatory proteins, and augments overall rate of proteolysis. Mechanistically, TRIM11 binds to both the proteasome and ... [more]
Nat Commun Dec. 26, 2017; 9(1);1223 [Pubmed: 29581427]
Throughput
- High Throughput
Curated By
- BioGRID