BAIT
ERBB4
Her4, c-erbB-4, AC167658.1
v-erb-a erythroblastic leukemia viral oncogene homolog 4 (avian)
GO Process (33)
GO Function (6)
GO Component (9)
Gene Ontology Biological Process
- cardiac muscle tissue regeneration [IMP]
- cell fate commitment [IDA]
- cell migration [ISO]
- central nervous system morphogenesis [IMP]
- embryonic pattern specification [IMP]
- heart development [IMP]
- lactation [IMP, ISO]
- mammary gland alveolus development [IMP]
- mammary gland epithelial cell differentiation [IMP]
- mitochondrial fragmentation involved in apoptotic process [ISO]
- negative regulation of apoptotic process [ISO]
- negative regulation of cell proliferation [ISO]
- negative regulation of muscle cell apoptotic process [ISO]
- nervous system development [IMP]
- neural crest cell migration [IMP]
- olfactory bulb interneuron differentiation [IMP]
- peptidyl-tyrosine phosphorylation [ISO]
- positive regulation of ERK1 and ERK2 cascade [ISO]
- positive regulation of STAT protein import into nucleus [IMP, ISO]
- positive regulation of cardiac muscle cell proliferation [IMP]
- positive regulation of cell migration [ISO]
- positive regulation of cell proliferation [ISO]
- positive regulation of epithelial cell proliferation [ISO]
- positive regulation of glucose import [ISO]
- positive regulation of synaptic transmission, GABAergic [ISO]
- positive regulation of transcription, DNA-templated [IMP, ISO]
- positive regulation of tyrosine phosphorylation of Stat5 protein [IMP, ISO]
- protein autophosphorylation [ISO]
- regulation of cell migration [IMP]
- signal transduction [ISO]
- surfactant homeostasis [ISO]
- synapse maturation [ISO]
- transmembrane receptor protein tyrosine kinase signaling pathway [ISO]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Mus musculus
PREY
ASAP2
6530401G17Rik, Ddef2, Gm1523, Gm592, PAG3, PAP
ArfGAP with SH3 domain, ankyrin repeat and PH domain 2
GO Process (0)
GO Function (0)
GO Component (0)
Mus musculus
Affinity Capture-MS
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods.
Publication
Neuregulin1 (NRG1) signaling through Fyn modulates NMDA receptor phosphorylation: differential synaptic function in NRG1+/- knock-outs compared with wild-type mice.
We previously identified Neuregulin1 (NRG1) as a gene contributing to the risk of developing schizophrenia. Furthermore, we showed that NRG1+/- mutant mice display behavioral abnormalities that are reversed by clozapine, an atypical antipsychotic drug used for the treatment of schizophrenia. We now present evidence that ErbB4 (v-erb-a erythroblastic leukemia viral oncogene homolog 4), the tyrosine kinase receptor for NRG1 in ... [more]
J. Neurosci. Apr. 25, 2007; 27(17);4519-29 [Pubmed: 17460065]
Throughput
- Low Throughput
Curated By
- BioGRID