SLC31A2
Gene Ontology Biological Process
Gene Ontology Cellular Component
RAMP1
Gene Ontology Biological Process
- angiogenesis [IDA]
- calcium ion transport [IDA]
- positive regulation of cAMP biosynthetic process [IDA]
- positive regulation of protein glycosylation [IDA]
- protein localization to plasma membrane [IDA]
- protein transport [IDA]
- receptor internalization [IDA]
- regulation of G-protein coupled receptor protein signaling pathway [IDA]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Reconstituted Complex
An interaction is inferred between proteins in vitro. This can include proteins in recombinant form or proteins isolated directly from cells with recombinant or purified bait. For example, GST pull-down assays where a GST-tagged protein is first isolated and then used to fish interactors from cell lysates are considered reconstituted complexes (e.g. PUBMED: 14657240, Fig. 4A or PUBMED: 14761940, Fig. 5). This can also include gel-shifts, surface plasmon resonance, isothermal titration calorimetry (ITC) and bio-layer interferometry (BLI) experiments. The bait-hit directionality may not be clear for 2 interacting proteins. In these cases the directionality is up to the discretion of the curator.
Publication
Characterization of the human calcitonin gene-related peptide receptor subtypes associated with receptor activity-modifying proteins.
Coexpression of receptor activity-modifying proteins (RAMPs) with calcitonin receptor 2 (CTR2) or calcitonin receptor-like receptor (CRLR) leads to the formation of four functional heterodimeric receptors for human calcitonin gene-related peptide (hCGRP). In this study, we transfected hCGRP receptors into human embryonic kidney 293 cells and examined their pharmacological profiles using three dominant-negative (DN) RAMP mutants and various hCGRPalpha analogs. Fluorescence-activated ... [more]
Throughput
- Low Throughput
Curated By
- BioGRID