PREY
ADRA1A
ADRA1C, ADRA1L1, ALPHA1AAR
adrenoceptor alpha 1A
GO Process (22)
GO Function (2)
GO Component (4)
Gene Ontology Biological Process
- G-protein coupled receptor signaling pathway [TAS]
- activation of phospholipase C activity [ISS]
- adrenergic receptor signaling pathway [ISS, NAS, TAS]
- aging [ISS]
- apoptotic process [TAS]
- calcium ion transport into cytosol [ISS]
- cell-cell signaling [TAS]
- intracellular signal transduction [TAS]
- negative regulation of Rho protein signal transduction [ISS]
- negative regulation of cell proliferation [TAS]
- positive regulation of ERK1 and ERK2 cascade [ISS]
- positive regulation of MAPK cascade [IDA]
- positive regulation of action potential [ISS]
- positive regulation of cardiac muscle contraction [ISS]
- positive regulation of cytosolic calcium ion concentration [ISS]
- positive regulation of protein kinase C signaling [ISS]
- positive regulation of synaptic transmission, GABAergic [ISS]
- positive regulation of vasoconstriction [ISS]
- response to drug [ISS]
- response to hormone [ISS]
- signal transduction [TAS]
- smooth muscle contraction [TAS]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
Affinity Capture-MS
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods.
Publication
E3 ubiquitin ligase RNF123 targets lamin B1 and lamin-binding proteins.
Lamins are key nuclear proteins which are important for maintaining nuclear structure and function. Mutations in lamins cause a spectrum of genetic diseases termed as laminopathies. RING finger containing E3 ubiquitin ligase, RNF123, is transcriptionally upregulated in cells expressing rod domain lamin A mutations. However, the functional relevance of RNF123 in laminopathic cells is not clear. Using a mass spectrometry-based ... [more]
FEBS J. Jun. 01, 2018; 285(12);2243-2262 [Pubmed: 29676528]
Throughput
- High Throughput
Curated By
- BioGRID