IGF1R
Gene Ontology Biological Process
- immune response [IMP]
- inactivation of MAPKK activity [IDA]
- insulin receptor signaling pathway [TAS]
- insulin-like growth factor receptor signaling pathway [IDA]
- negative regulation of apoptotic process [IDA]
- peptidyl-tyrosine autophosphorylation [IMP]
- phosphatidylinositol 3-kinase signaling [IC]
- phosphatidylinositol-mediated signaling [IDA]
- positive regulation of DNA replication [IMP]
- positive regulation of cell migration [IMP]
- positive regulation of cell proliferation [TAS]
- protein autophosphorylation [IDA]
- protein tetramerization [IDA]
- regulation of JNK cascade [IDA]
- signal transduction [TAS]
Gene Ontology Molecular Function- identical protein binding [IPI]
- insulin binding [IPI]
- insulin receptor binding [IDA]
- insulin receptor substrate binding [IPI]
- insulin-like growth factor I binding [IPI]
- insulin-like growth factor binding [IDA]
- insulin-like growth factor-activated receptor activity [IDA]
- phosphatidylinositol 3-kinase binding [IPI]
- protein binding [IPI]
- protein tyrosine kinase activity [IDA, TAS]
- identical protein binding [IPI]
- insulin binding [IPI]
- insulin receptor binding [IDA]
- insulin receptor substrate binding [IPI]
- insulin-like growth factor I binding [IPI]
- insulin-like growth factor binding [IDA]
- insulin-like growth factor-activated receptor activity [IDA]
- phosphatidylinositol 3-kinase binding [IPI]
- protein binding [IPI]
- protein tyrosine kinase activity [IDA, TAS]
Gene Ontology Cellular Component
HDAC3
Gene Ontology Biological Process
- Notch signaling pathway [TAS]
- cellular lipid metabolic process [TAS]
- cellular response to fluid shear stress [IDA]
- chromatin modification [TAS]
- negative regulation of JNK cascade [IMP]
- negative regulation of apoptotic process [TAS]
- negative regulation of cell cycle [TAS]
- negative regulation of myotube differentiation [IMP]
- negative regulation of transcription from RNA polymerase II promoter [IDA, IMP]
- negative regulation of transcription, DNA-templated [IMP]
- neurotrophin TRK receptor signaling pathway [TAS]
- positive regulation of TOR signaling [IMP]
- positive regulation of protein phosphorylation [IDA]
- positive regulation of transcription factor import into nucleus [IDA]
- positive regulation of transcription from RNA polymerase II promoter [IDA]
- protein deacetylation [IDA]
- regulation of protein stability [IDA]
- small molecule metabolic process [TAS]
- spindle assembly [IMP]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Affinity Capture-Western
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner identified by Western blot with a specific polyclonal antibody or second epitope tag. This category is also used if an interacting protein is visualized directly by dye stain or radioactivity. Note that this differs from any co-purification experiment involving affinity capture in that the co-purification experiment involves at least one extra purification step to get rid of potential contaminating proteins.
Publication
Dual inhibition of AKT-mTOR and AR signaling by targeting HDAC3 in PTEN- or SPOP-mutated prostate cancer.
AKT-mTOR and androgen receptor (AR) signaling pathways are aberrantly activated in prostate cancer due to frequent PTEN deletions or SPOP mutations. A clinical barrier is that targeting one of them often activates the other. Here, we demonstrate that HDAC3 augments AKT phosphorylation in prostate cancer cells and its overexpression correlates with AKT phosphorylation in patient samples. HDAC3 facilitates lysine-63-chain polyubiquitination ... [more]
Throughput
- Low Throughput
Curated By
- BioGRID