PPT1
Gene Ontology Biological Process
- brain development [IMP]
- cofactor metabolic process [IMP]
- cofactor transport [IMP]
- lipid catabolic process [IDA]
- lysosomal lumen acidification [IMP]
- membrane raft organization [IMP]
- negative regulation of apoptotic process [IDA]
- negative regulation of cell growth [IMP]
- negative regulation of neuron apoptotic process [IMP]
- nervous system development [IMP]
- neuron development [TAS]
- pinocytosis [IMP]
- positive regulation of pinocytosis [IMP]
- positive regulation of receptor-mediated endocytosis [IMP]
- protein catabolic process [NAS]
- protein depalmitoylation [IDA, ISS]
- protein transport [IMP]
- receptor-mediated endocytosis [IMP]
- regulation of synapse structure or activity [NAS]
- sphingolipid catabolic process [TAS]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
MAP1B
Gene Ontology Biological Process
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Affinity Capture-MS
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods.
Publication
Quantitative analysis of PPT1 interactome in human neuroblastoma cells.
Mutations in the CLN1 gene that encodes Palmitoyl protein thioesterase 1 (PPT1) or CLN1, cause Infantile NCL (INCL, MIM#256730). PPT1 removes long fatty acid chains such as palmitate from modified cysteine residues of proteins. The data shown here result from isolated protein complexes from PPT1-expressing SH-SY5Y stable cells that were subjected to single step affinity purification coupled to mass spectrometry ... [more]
Throughput
- High Throughput
Related interactions
| Interaction | Experimental Evidence Code | Dataset | Throughput | Score | Curated By | Notes |
|---|---|---|---|---|---|---|
| PPT1 MAP1B | Affinity Capture-MS Affinity Capture-MS An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods. | High | - | BioGRID | 1107218 |
Curated By
- BioGRID