PPT1
Gene Ontology Biological Process
- brain development [IMP]
- cofactor metabolic process [IMP]
- cofactor transport [IMP]
- lipid catabolic process [IDA]
- lysosomal lumen acidification [IMP]
- membrane raft organization [IMP]
- negative regulation of apoptotic process [IDA]
- negative regulation of cell growth [IMP]
- negative regulation of neuron apoptotic process [IMP]
- nervous system development [IMP]
- neuron development [TAS]
- pinocytosis [IMP]
- positive regulation of pinocytosis [IMP]
- positive regulation of receptor-mediated endocytosis [IMP]
- protein catabolic process [NAS]
- protein depalmitoylation [IDA, ISS]
- protein transport [IMP]
- receptor-mediated endocytosis [IMP]
- regulation of synapse structure or activity [NAS]
- sphingolipid catabolic process [TAS]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
VAPB
Gene Ontology Biological Process
- COPII-coated vesicle budding [IMP]
- ER to Golgi vesicle-mediated transport [IMP]
- activation of signaling protein activity involved in unfolded protein response [IDA]
- cellular calcium ion homeostasis [IMP]
- endoplasmic reticulum organization [IMP]
- endoplasmic reticulum unfolded protein response [IMP]
- modulation by virus of host morphology or physiology [IDA]
- negative regulation by host of viral genome replication [IDA]
- negative regulation by host of viral release from host cell [IDA]
- negative regulation by virus of viral protein levels in host cell [IDA]
- positive regulation by host of viral genome replication [IDA]
- positive regulation by host of viral release from host cell [IDA]
- positive regulation of viral genome replication [IMP]
- small molecule metabolic process [TAS]
- sphingolipid biosynthetic process [TAS]
- sphingolipid metabolic process [TAS]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Affinity Capture-MS
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods.
Publication
Quantitative analysis of PPT1 interactome in human neuroblastoma cells.
Mutations in the CLN1 gene that encodes Palmitoyl protein thioesterase 1 (PPT1) or CLN1, cause Infantile NCL (INCL, MIM#256730). PPT1 removes long fatty acid chains such as palmitate from modified cysteine residues of proteins. The data shown here result from isolated protein complexes from PPT1-expressing SH-SY5Y stable cells that were subjected to single step affinity purification coupled to mass spectrometry ... [more]
Throughput
- High Throughput
Related interactions
| Interaction | Experimental Evidence Code | Dataset | Throughput | Score | Curated By | Notes |
|---|---|---|---|---|---|---|
| PPT1 VAPB | Affinity Capture-MS Affinity Capture-MS An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods. | High | - | BioGRID | 1107219 |
Curated By
- BioGRID