BAIT
PPT1
CLN1, INCL, PPT, RP11-115D7.2
palmitoyl-protein thioesterase 1
GO Process (20)
GO Function (2)
GO Component (10)
Gene Ontology Biological Process
- brain development [IMP]
- cofactor metabolic process [IMP]
- cofactor transport [IMP]
- lipid catabolic process [IDA]
- lysosomal lumen acidification [IMP]
- membrane raft organization [IMP]
- negative regulation of apoptotic process [IDA]
- negative regulation of cell growth [IMP]
- negative regulation of neuron apoptotic process [IMP]
- nervous system development [IMP]
- neuron development [TAS]
- pinocytosis [IMP]
- positive regulation of pinocytosis [IMP]
- positive regulation of receptor-mediated endocytosis [IMP]
- protein catabolic process [NAS]
- protein depalmitoylation [IDA, ISS]
- protein transport [IMP]
- receptor-mediated endocytosis [IMP]
- regulation of synapse structure or activity [NAS]
- sphingolipid catabolic process [TAS]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
PREY
DNM1L
DLP1, DRP1, DVLP, DYMPLE, EMPF, HDYNIV
dynamin 1-like
GO Process (21)
GO Function (5)
GO Component (11)
Gene Ontology Biological Process
- GTP catabolic process [IDA]
- apoptotic process [TAS]
- cellular component disassembly involved in execution phase of apoptosis [TAS]
- dynamin polymerization involved in mitochondrial fission [IDA]
- membrane fission involved in mitochondrial fission [IDA]
- membrane fusion [IDA]
- mitochondrial fission [IDA, IMP]
- mitochondrial fragmentation involved in apoptotic process [IMP]
- mitochondrion morphogenesis [IMP]
- necroptotic process [IMP]
- peroxisome fission [IDA, IMP]
- positive regulation of apoptotic process [IMP]
- positive regulation of intrinsic apoptotic signaling pathway [IMP]
- positive regulation of mitochondrial fission [TAS]
- positive regulation of protein secretion [IDA]
- positive regulation of release of cytochrome c from mitochondria [IMP]
- protein homotetramerization [IDA]
- regulation of mitochondrion organization [IMP]
- regulation of peroxisome organization [IMP]
- regulation of protein oligomerization [IDA]
- release of cytochrome c from mitochondria [IMP]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
Affinity Capture-MS
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods.
Publication
Quantitative analysis of PPT1 interactome in human neuroblastoma cells.
Mutations in the CLN1 gene that encodes Palmitoyl protein thioesterase 1 (PPT1) or CLN1, cause Infantile NCL (INCL, MIM#256730). PPT1 removes long fatty acid chains such as palmitate from modified cysteine residues of proteins. The data shown here result from isolated protein complexes from PPT1-expressing SH-SY5Y stable cells that were subjected to single step affinity purification coupled to mass spectrometry ... [more]
Data Brief Sep. 01, 2015; 4();207-16 [Pubmed: 26217791]
Throughput
- High Throughput
Curated By
- BioGRID