PTPRT
Gene Ontology Biological Process
Gene Ontology Molecular Function
Gene Ontology Cellular Component
NRXN1
Gene Ontology Biological Process
- N-methyl-D-aspartate receptor clustering [ISS]
- adult behavior [ISO, ISS]
- angiogenesis [ISS]
- calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules [ISS]
- cerebellar granule cell differentiation [ISS]
- establishment of protein localization [ISS]
- gamma-aminobutyric acid receptor clustering [ISS]
- gephyrin clustering [ISO, ISS]
- guanylate kinase-associated protein clustering [ISS]
- heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules [ISS]
- learning [ISO, ISS]
- negative regulation of filopodium assembly [ISS]
- neuroligin clustering [ISO, ISS]
- neuromuscular process controlling balance [ISO, ISS]
- neuron cell-cell adhesion [ISS]
- neurotransmitter secretion [ISO, ISS]
- positive regulation of establishment of protein localization to plasma membrane [ISS]
- positive regulation of excitatory postsynaptic membrane potential [ISO, ISS]
- positive regulation of synapse assembly [ISO, ISS]
- positive regulation of synapse maturation [ISO, ISS]
- positive regulation of synaptic transmission, glutamatergic [ISO, ISS]
- postsynaptic density protein 95 clustering [ISO, ISS]
- postsynaptic membrane assembly [ISO, ISS]
- prepulse inhibition [ISO, ISS]
- presynaptic membrane assembly [ISS]
- protein complex assembly involved in synapse maturation [ISS]
- protein heterotetramerization [IDA]
- protein localization to synapse [ISS]
- receptor localization to synapse [ISS]
- regulation of N-methyl-D-aspartate selective glutamate receptor activity [ISS]
- regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor activity [ISS]
- regulation of grooming behavior [ISO, ISS]
- regulation of insulin secretion involved in cellular response to glucose stimulus [ISO]
- social behavior [ISO]
- synapse assembly [ISO, ISS]
- synaptic transmission [ISO, ISS]
- synaptic vesicle clustering [ISS]
- vesicle docking involved in exocytosis [IMP]
- vocal learning [ISO]
- vocalization behavior [ISO]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Affinity Capture-Western
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner identified by Western blot with a specific polyclonal antibody or second epitope tag. This category is also used if an interacting protein is visualized directly by dye stain or radioactivity. Note that this differs from any co-purification experiment involving affinity capture in that the co-purification experiment involves at least one extra purification step to get rid of potential contaminating proteins.
Publication
Synapse formation regulated by protein tyrosine phosphatase receptor T through interaction with cell adhesion molecules and Fyn.
The receptor-type protein tyrosine phosphatases (RPTPs) have been linked to signal transduction, cell adhesion, and neurite extension. PTPRT/RPTPrho is exclusively expressed in the central nervous system and regulates synapse formation by interacting with cell adhesion molecules and Fyn protein tyrosine kinase. Overexpression of PTPRT in cultured neurons increased the number of excitatory and inhibitory synapses by recruiting neuroligins that interact ... [more]
Throughput
- Low Throughput
Related interactions
| Interaction | Experimental Evidence Code | Dataset | Throughput | Score | Curated By | Notes |
|---|---|---|---|---|---|---|
| NRXN1 PTPRT | Affinity Capture-Western Affinity Capture-Western An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner identified by Western blot with a specific polyclonal antibody or second epitope tag. This category is also used if an interacting protein is visualized directly by dye stain or radioactivity. Note that this differs from any co-purification experiment involving affinity capture in that the co-purification experiment involves at least one extra purification step to get rid of potential contaminating proteins. | Low | - | BioGRID | - | |
| NRXN1 PTPRT | Reconstituted Complex Reconstituted Complex An interaction is inferred between proteins in vitro. This can include proteins in recombinant form or proteins isolated directly from cells with recombinant or purified bait. For example, GST pull-down assays where a GST-tagged protein is first isolated and then used to fish interactors from cell lysates are considered reconstituted complexes (e.g. PUBMED: 14657240, Fig. 4A or PUBMED: 14761940, Fig. 5). This can also include gel-shifts, surface plasmon resonance, isothermal titration calorimetry (ITC) and bio-layer interferometry (BLI) experiments. The bait-hit directionality may not be clear for 2 interacting proteins. In these cases the directionality is up to the discretion of the curator. | Low | - | BioGRID | - | |
| PTPRT NRXN1 | Reconstituted Complex Reconstituted Complex An interaction is inferred between proteins in vitro. This can include proteins in recombinant form or proteins isolated directly from cells with recombinant or purified bait. For example, GST pull-down assays where a GST-tagged protein is first isolated and then used to fish interactors from cell lysates are considered reconstituted complexes (e.g. PUBMED: 14657240, Fig. 4A or PUBMED: 14761940, Fig. 5). This can also include gel-shifts, surface plasmon resonance, isothermal titration calorimetry (ITC) and bio-layer interferometry (BLI) experiments. The bait-hit directionality may not be clear for 2 interacting proteins. In these cases the directionality is up to the discretion of the curator. | Low | - | BioGRID | - |
Curated By
- BioGRID