BAIT

STARD13

ARHGAP37, DLC2, GT650, LINC00464, RP11-81F11.1

StAR-related lipid transfer (START) domain containing 13

GO Process (2)

GO Function (1)

GO Component (1)

Gene Ontology Biological Process

regulation of small GTPase mediated signal transduction [TAS]

small GTPase mediated signal transduction [TAS]

Gene Ontology Molecular Function

protein binding [IPI]

Gene Ontology Cellular Component

CRISPR Database HGNC Alliance of Genome Resources OMIM VEGA Entrez Gene RefSeq UniprotKB Ensembl HPRD

Homo sapiens

PREY

ITPR1

ACV, CLA4, INSP3R1, IP3R, IP3R1, PPP1R94, SCA15, SCA16, SCA29

inositol 1,4,5-trisphosphate receptor, type 1

GO Process (19)

GO Function (6)

GO Component (6)

Gene Ontology Biological Process

Fc-epsilon receptor signaling pathway [TAS]

Fc-gamma receptor signaling pathway involved in phagocytosis [TAS]

activation of phospholipase C activity [TAS]

blood coagulation [TAS]

calcium ion transport [NAS]

energy reserve metabolic process [TAS]

epidermal growth factor receptor signaling pathway [TAS]

fibroblast growth factor receptor signaling pathway [TAS]

innate immune response [TAS]

inositol phosphate-mediated signaling [ISS, TAS]

intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress [ISS]

negative regulation of calcium-mediated signaling [IDA]

neurotrophin TRK receptor signaling pathway [TAS]

platelet activation [TAS]

regulation of insulin secretion [TAS]

release of sequestered calcium ion into cytosol [ISS]

response to hypoxia [IDA]

signal transduction [NAS, TAS]

small molecule metabolic process [TAS]

Gene Ontology Molecular Function

calcium channel inhibitor activity [IDA]
calcium ion transmembrane transporter activity [TAS]
inositol 1,4,5-trisphosphate-sensitive calcium-release channel activity [ISS, TAS]
intracellular ligand-gated calcium channel activity [ISS]
phosphatidylinositol binding [ISS]
protein binding [IPI]

Gene Ontology Cellular Component

endoplasmic reticulum [NAS]

endoplasmic reticulum membrane [TAS]

platelet dense granule membrane [IDA]

platelet dense tubular network [IDA]

platelet dense tubular network membrane [TAS]

CRISPR Database HGNC Alliance of Genome Resources VEGA OMIM Entrez Gene RefSeq UniprotKB Ensembl HPRD

Homo sapiens

Two-hybrid

Bait protein expressed as a DNA binding domain (DBD) fusion and prey expressed as a transcriptional activation domain (TAD) fusion and interaction measured by reporter gene activation.

Publication

Chromosome 13q12 encoded Rho GTPase activating protein suppresses growth of breast carcinoma cells, and yeast two-hybrid screen shows its interaction with several proteins.

Nagaraja GM, Kandpal RP

We have characterized the cDNA for a Rho GTPase activating protein (GAP) mapping to chromosome 13q12. The cDNA was characterized by determining the complete sequence of a 4.8 kb cDNA clone that represents the 5' untranslated region (UTR), the translated region, and the 3' UTR. The protein has a sterile alpha-motif (SAM), a distinct GAP domain, and a conserved START ... [more]

Biochem. Biophys. Res. Commun. Jan. 16, 2004; 313(3);654-65 [Pubmed: 14697242]

Throughput

Low Throughput

Curated By

BioGRID