BAIT
ARAP3
CENTD3, DRAG1
ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 3
GO Process (7)
GO Function (6)
GO Component (4)
Gene Ontology Biological Process
- cytoskeleton organization [TAS]
- negative regulation of Rho protein signal transduction [ISS]
- negative regulation of cell migration [ISS]
- regulation of cell shape [ISS]
- regulation of small GTPase mediated signal transduction [TAS]
- small GTPase mediated signal transduction [TAS]
- vesicle-mediated transport [TAS]
Gene Ontology Molecular Function
Homo sapiens
PREY
GGA3
golgi-associated, gamma adaptin ear containing, ARF binding protein 3
GO Process (1)
GO Function (2)
GO Component (1)
Gene Ontology Biological Process
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
Two-hybrid
Bait protein expressed as a DNA binding domain (DBD) fusion and prey expressed as a transcriptional activation domain (TAD) fusion and interaction measured by reporter gene activation.
Publication
The PI3K effector Arap3 interacts with the PI(3,4,5)P3 phosphatase SHIP2 in a SAM domain-dependent manner.
Arap3 is a phosphoinositide (PI) 3 kinase effector that serves as a GTPase activating protein (GAP) for both Arf and Rho G-proteins. The protein has multiple pleckstrin homology (PH) domains that bind preferentially phosphatidyl-inositol-3,4,5-trisphosphate (PI(3,4,5,)P3) to induce translocation of Arap3 to the plasma membrane upon PI3K activation. Arap3 also contains a Ras association (RA) domain that interacts with the small ... [more]
Cell. Signal. Jun. 01, 2007; 19(6);1249-57 [Pubmed: 17314030]
Throughput
- High Throughput
Curated By
- BioGRID