USP8
Gene Ontology Biological Process
- cell proliferation [TAS]
- endosome organization [IMP]
- mitotic cytokinesis [IMP]
- proteasome-mediated ubiquitin-dependent protein catabolic process [IBA]
- protein K48-linked deubiquitination [IDA]
- protein K63-linked deubiquitination [IDA]
- protein deubiquitination [IMP]
- regulation of proteasomal protein catabolic process [IBA]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
SHANK1
Gene Ontology Biological Process
- adult behavior [IMP]
- associative learning [ISS]
- cytoskeletal anchoring at plasma membrane [NAS]
- dendritic spine morphogenesis [ISS]
- determination of affect [IMP]
- long-term memory [ISS]
- negative regulation of actin filament bundle assembly [ISS]
- neuromuscular process controlling balance [ISS]
- positive regulation of dendritic spine development [ISS]
- positive regulation of excitatory postsynaptic membrane potential [ISS]
- protein complex assembly [ISS]
- protein localization to synapse [ISS]
- regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor activity [ISS]
- social behavior [IMP]
- synapse maturation [ISS]
- vocalization behavior [IMP]
Gene Ontology Molecular Function- GKAP/Homer scaffold activity [ISS]
- SH3 domain binding [ISS]
- ankyrin repeat binding [ISS]
- identical protein binding [ISS]
- ionotropic glutamate receptor binding [ISS]
- protein C-terminus binding [ISS]
- protein binding [IPI]
- protein complex binding [ISS]
- scaffold protein binding [ISS]
- somatostatin receptor binding [ISS]
- GKAP/Homer scaffold activity [ISS]
- SH3 domain binding [ISS]
- ankyrin repeat binding [ISS]
- identical protein binding [ISS]
- ionotropic glutamate receptor binding [ISS]
- protein C-terminus binding [ISS]
- protein binding [IPI]
- protein complex binding [ISS]
- scaffold protein binding [ISS]
- somatostatin receptor binding [ISS]
Gene Ontology Cellular Component
- N-methyl-D-aspartate selective glutamate receptor complex [ISS]
- dendrite [NAS]
- dendritic spine [ISS]
- excitatory synapse [ISS]
- intracellular [NAS]
- ionotropic glutamate receptor complex [ISS]
- membrane [IDA]
- neuron projection [ISS]
- neuronal postsynaptic density [ISS]
- plasma membrane [ISS]
- postsynaptic membrane [ISS]
Biochemical Activity (Deubiquitination)
An interaction is inferred from the biochemical effect of one protein upon another, for example, GTP-GDP exchange activity or phosphorylation of a substrate by a kinase. The bait protein executes the activity on the substrate hit protein. A Modification value is recorded for interactions of this type with the possible values Phosphorylation, Ubiquitination, Sumoylation, Dephosphorylation, Methylation, Prenylation, Acetylation, Deubiquitination, Proteolytic Processing, Glucosylation, Nedd(Rub1)ylation, Deacetylation, No Modification, Demethylation.
Publication
USP8 Deubiquitinates SHANK3 to Control Synapse Density and SHANK3 Activity-Dependent Protein Levels.
Mutations or altered protein levels of SHANK3 are implicated in neurodevelopmental disorders such as Phelan-McDermid syndrome, autism spectrum disorders, and schizophrenia (Guilmatre et al., 2014). Loss of SHANK3 in mouse models results in decreased synapse density and reduction in the levels of multiple synaptic proteins (Jiang and Ehlers, 2013). The family of SHANK scaffolding molecules are among the most heavily ... [more]
Throughput
- Low Throughput
Curated By
- BioGRID