STUB1
Gene Ontology Biological Process
- cellular response to misfolded protein [ISO]
- misfolded or incompletely synthesized protein catabolic process [ISO]
- positive regulation of chaperone-mediated protein complex assembly [ISO]
- positive regulation of proteasomal ubiquitin-dependent protein catabolic process [ISO]
- positive regulation of protein ubiquitination [ISO]
- proteasome-mediated ubiquitin-dependent protein catabolic process [ISO]
- protein K63-linked ubiquitination [ISO]
- protein autoubiquitination [ISO]
- protein polyubiquitination [ISO]
- regulation of glucocorticoid metabolic process [ISO]
- ubiquitin-dependent SMAD protein catabolic process [ISO]
- ubiquitin-dependent protein catabolic process [ISO]
Gene Ontology Molecular Function- G-protein coupled receptor binding [ISO]
- Hsp70 protein binding [ISO]
- Hsp90 protein binding [ISO]
- SMAD binding [ISO]
- TPR domain binding [ISO]
- enzyme binding [ISO]
- kinase binding [ISO]
- misfolded protein binding [ISO]
- protein binding [IPI]
- protein homodimerization activity [ISO]
- ubiquitin protein ligase activity [ISO]
- ubiquitin protein ligase binding [ISO]
- ubiquitin-protein transferase activity [ISO]
- ubiquitin-ubiquitin ligase activity [ISO]
- G-protein coupled receptor binding [ISO]
- Hsp70 protein binding [ISO]
- Hsp90 protein binding [ISO]
- SMAD binding [ISO]
- TPR domain binding [ISO]
- enzyme binding [ISO]
- kinase binding [ISO]
- misfolded protein binding [ISO]
- protein binding [IPI]
- protein homodimerization activity [ISO]
- ubiquitin protein ligase activity [ISO]
- ubiquitin protein ligase binding [ISO]
- ubiquitin-protein transferase activity [ISO]
- ubiquitin-ubiquitin ligase activity [ISO]
Gene Ontology Cellular Component
PTPN6
Gene Ontology Biological Process
- B cell receptor signaling pathway [ISO]
- abortive mitotic cell cycle [ISO]
- cell differentiation [ISO, ISS]
- cell proliferation [ISO, ISS]
- hematopoietic progenitor cell differentiation [ISO]
- intracellular signal transduction [ISO]
- megakaryocyte development [ISO]
- natural killer cell mediated cytotoxicity [ISO]
- negative regulation of B cell receptor signaling pathway [ISO]
- negative regulation of MAP kinase activity [ISO]
- negative regulation of MAPK cascade [ISO]
- negative regulation of T cell proliferation [ISO]
- negative regulation of T cell receptor signaling pathway [ISO]
- negative regulation of humoral immune response mediated by circulating immunoglobulin [ISO]
- negative regulation of peptidyl-tyrosine phosphorylation [ISO]
- peptidyl-tyrosine dephosphorylation [ISO, ISS, TAS]
- peptidyl-tyrosine phosphorylation [ISO]
- platelet aggregation [ISO]
- platelet formation [ISO]
- positive regulation of cell adhesion mediated by integrin [ISO]
- positive regulation of cell proliferation [ISO]
- positive regulation of phosphatidylinositol 3-kinase signaling [ISO]
- protein dephosphorylation [ISO, ISS, TAS]
- regulation of B cell differentiation [ISO]
- regulation of ERK1 and ERK2 cascade [ISO, ISS]
- regulation of G1/S transition of mitotic cell cycle [ISO]
- regulation of release of sequestered calcium ion into cytosol [ISO]
- response to wounding [IEP]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Affinity Capture-Western
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner identified by Western blot with a specific polyclonal antibody or second epitope tag. This category is also used if an interacting protein is visualized directly by dye stain or radioactivity. Note that this differs from any co-purification experiment involving affinity capture in that the co-purification experiment involves at least one extra purification step to get rid of potential contaminating proteins.
Publication
Protection against doxorubicin-induced myocardial dysfunction in mice by cardiac-specific expression of carboxyl terminus of hsp70-interacting protein.
Carboxyl terminus of Hsp70-interacting protein (CHIP) is a critical ubiquitin ligase/cochaperone to reduce cardiac oxidative stress, inflammation, cardiomyocyte apoptosis and autophage etc. However, it is unclear whether overexpression of CHIP in the heart would exert protective effects against DOX-induced cardiomyopathy. Cardiac-specific CHIP transgenic (CHIP-TG) mice and the wild-type (WT) littermates were treated with DOX or saline. DOX-induced cardiac atrophy, dysfunction, ... [more]
Throughput
- Low Throughput
Curated By
- BioGRID