BAIT
RABGEF1
Rab5ef, Rabex5, Rin2
RAB guanine nucleotide exchange factor (GEF) 1
GO Process (13)
GO Function (4)
GO Component (2)
Gene Ontology Biological Process
- negative regulation of Kit signaling pathway [IMP]
- negative regulation of Ras protein signal transduction [IMP]
- negative regulation of inflammatory response [IMP]
- negative regulation of interleukin-6 secretion [IMP]
- negative regulation of leukocyte migration [IMP]
- negative regulation of mast cell activation [IMP]
- negative regulation of mast cell degranulation [IMP]
- negative regulation of protein phosphorylation [IMP]
- negative regulation of receptor-mediated endocytosis [IMP]
- positive regulation of Rab GTPase activity [ISO]
- protein targeting to membrane [ISO]
- protein ubiquitination [IDA]
- regulation of Fc receptor mediated stimulatory signaling pathway [IDA, IMP]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Mus musculus
PREY
UBC
2700054O04Rik, AI194771, Rps27a, TI-225, Uba52, Ubb
ubiquitin C
GO Process (1)
GO Function (3)
GO Component (2)
Gene Ontology Biological Process
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Mus musculus
Reconstituted Complex
An interaction is detected between purified proteins in vitro.
Publication
Endosomal Rab cycles regulate Parkin-mediated mitophagy.
Damaged mitochondria are selectively eliminated by mitophagy. Parkin and PINK1, gene products mutated in familial Parkinson's disease, play essential roles in mitophagy through ubiquitination of mitochondria. Cargo ubiquitination by E3 ubiquitin ligase Parkin is important to trigger selective autophagy. Although autophagy receptors recruit LC3-labeled autophagic membranes onto damaged mitochondria, how other essential autophagy units such as ATG9A-integrated vesicles are recruited ... [more]
Elife Dec. 23, 2017; 7(); [Pubmed: 29360040]
Throughput
- Low Throughput
Additional Notes
- #LPPI
- likely protein-protein interaction
Related interactions
| Interaction | Experimental Evidence Code | Dataset | Throughput | Score | Curated By | Notes |
|---|---|---|---|---|---|---|
| UBC RABGEF1 | Reconstituted Complex Reconstituted Complex An interaction is detected between purified proteins in vitro. | High | - | BioGRID | 2297428 |
Curated By
- BioGRID