An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods.

Publication

SUMO-specific protease 2 (SENP2) suppresses keratinocyte migration by targeting NDR1 for de-SUMOylation.

Xiao N, Li H, Yu W, Gu C, Fang H, Peng Y, Mao H, Fang Y, Ni W, Yao M

A key member of the sentrin/small ubiquitin-like modifier (SUMO)-specific protease (SENP) family, SENP2 has been shown to implicate embryonic development, fatty acid metabolism, atherosclerosis, and neurodegenerative diseases. However, other biologic functions of SENP2 and its specific targets are incompletely understood. Here, we uncovered a novel role of SENP2 in negative regulation of keratinocyte migration, a process crucial to wound epithelialization. ... [more]

FASEB J. Jan. 01, 2019; 33(1);163-174 [Pubmed: 29969578]

Throughput

High Throughput

Related interactions

Interaction	Experimental Evidence Code	Dataset	Throughput	Score	Curated By	Notes
LMNB1 SENP2	Proximity Label-MS Proximity Label-MS An interaction is inferred when a bait-enzyme fusion protein selectively modifies a vicinal protein with a diffusible reactive product, followed by affinity capture of the modified protein and identification by mass spectrometric methods.	Go CD (2021)	High	95	BioGRID	2994760

Curated By

BioGRID

Interaction Summary

SENP2

Gene Ontology Biological Process

Gene Ontology Molecular Function

SUMO-specific protease activity [IDA]protein binding [IPI]

Gene Ontology Cellular Component

LMNB1