BAIT
NBN
AT-V1, AT-V2, ATV, NBS, NBS1, P95
nibrin
GO Process (13)
GO Function (5)
GO Component (8)
Gene Ontology Biological Process
- DNA damage checkpoint [IDA]
- DNA damage response, signal transduction by p53 class mediator [TAS]
- DNA duplex unwinding [IMP]
- DNA repair [TAS]
- cell cycle arrest [TAS]
- double-strand break repair [IDA, TAS]
- double-strand break repair via homologous recombination [TAS]
- mitotic G2 DNA damage checkpoint [IDA]
- mitotic cell cycle checkpoint [IDA]
- positive regulation of kinase activity [IDA]
- positive regulation of protein autophosphorylation [IDA]
- regulation of DNA-dependent DNA replication initiation [TAS]
- telomere maintenance [IMP]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
PREY
EEF2
EEF-2, EF-2, EF2, SCA26
eukaryotic translation elongation factor 2
GO Process (6)
GO Function (4)
GO Component (8)
Gene Ontology Biological Process
Gene Ontology Molecular Function
Homo sapiens
Affinity Capture-MS
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods.
Publication
Ubiquitin-specific protease 7 sustains DNA damage response and promotes cervical carcinogenesis.
Central to the recognition, signaling, and repair of DNA double-strand breaks (DSBs) are the MRE11-RAD50-NBS1 (MRN) complex and mediator of DNA damage checkpoint protein 1 (MDC1), the interplay of which is essential for initiation and amplification of the DNA damage response (DDR). The intrinsic rule governing the regulation of the function of this molecular machinery remains to be investigated. We ... [more]
J. Clin. Invest. Oct. 01, 2018; 128(10);4280-4296 [Pubmed: 30179224]
Throughput
- High Throughput
Additional Notes
- Source of NBN not clear
Curated By
- BioGRID