AQP3
Gene Ontology Biological Process
- carbohydrate transmembrane transport [IBA]
- cellular water homeostasis [IBA]
- excretion [TAS]
- ion transmembrane transport [IBA]
- odontogenesis [IEP]
- positive regulation of immune system process [IDA]
- regulation of keratinocyte differentiation [TAS]
- response to calcium ion [TAS]
- response to retinoic acid [IDA]
- response to vitamin D [TAS]
- transmembrane transport [TAS]
- transport [NAS]
- urea transmembrane transport [IBA]
- water transport [TAS]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
PLD2
Gene Ontology Biological Process
- Fc-gamma receptor signaling pathway involved in phagocytosis [TAS]
- cytoskeleton organization [TAS]
- glycerophospholipid biosynthetic process [TAS]
- innate immune response [TAS]
- phosphatidic acid biosynthetic process [TAS]
- phosphatidylglycerol biosynthetic process [TAS]
- phospholipid metabolic process [TAS]
- small GTPase mediated signal transduction [TAS]
- small molecule metabolic process [TAS]
- synaptic vesicle recycling [TAS]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Affinity Capture-Western
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner identified by Western blot with a specific polyclonal antibody or second epitope tag. This category is also used if an interacting protein is visualized directly by dye stain or radioactivity. Note that this differs from any co-purification experiment involving affinity capture in that the co-purification experiment involves at least one extra purification step to get rid of potential contaminating proteins.
Publication
Aquaporin 3 colocates with phospholipase d2 in caveolin-rich membrane microdomains and is downregulated upon keratinocyte differentiation.
Aquaporin 3 is a channel that transports both water and glycerol. Aquaporin 3-deficient mice exhibit skin defects, including decreased glycerol content and impairment of water holding capacity, barrier recovery, and wound healing. Whether aquaporin 3 and its glycerol transporting capacity are involved in regulating keratinocyte function, we have previously shown that phospholipase D2 can metabolize phospholipids in the presence of ... [more]
Throughput
- Low Throughput
Related interactions
| Interaction | Experimental Evidence Code | Dataset | Throughput | Score | Curated By | Notes |
|---|---|---|---|---|---|---|
| PLD2 AQP3 | Affinity Capture-Western Affinity Capture-Western An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner identified by Western blot with a specific polyclonal antibody or second epitope tag. This category is also used if an interacting protein is visualized directly by dye stain or radioactivity. Note that this differs from any co-purification experiment involving affinity capture in that the co-purification experiment involves at least one extra purification step to get rid of potential contaminating proteins. | Low | - | BioGRID | - |
Curated By
- BioGRID