BAIT
ELAVL1
ELAV1, HUR, Hua, MelG
ELAV like RNA binding protein 1
GO Process (8)
GO Function (9)
GO Component (5)
Gene Ontology Biological Process
Gene Ontology Molecular Function
Homo sapiens
PREY
BECN1
ATG6, VPS30, beclin1
beclin 1, autophagy related
GO Process (10)
GO Function (1)
GO Component (5)
Gene Ontology Biological Process
- CVT pathway [IBA]
- autophagic vacuole assembly [IBA]
- cellular defense response [TAS]
- cellular response to nitrogen starvation [IBA]
- cytokinesis [IMP]
- late endosome to vacuole transport [IBA]
- negative regulation of apoptotic process [TAS]
- nucleophagy [IBA]
- positive regulation of autophagy [IMP]
- positive regulation of mitochondrion degradation [IMP]
Gene Ontology Molecular Function
Homo sapiens
Affinity Capture-RNA
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and associated RNA species identified by Northern blot, RT-PCR, affinity labeling, sequencing, or microarray analysis.
Publication
Activation of ferritinophagy is required for the RNA-binding protein ELAVL1/HuR to regulate ferroptosis in hepatic stellate cells.
Ferroptosis is a recently recognized form of regulated cell death that is characterized by lipid peroxidation. However, the molecular mechanisms regulating ferroptosis are largely unknown. In this study, we report that the RNA-binding protein ELAVL1/HuR plays a crucial role in regulating ferroptosis in liver fibrosis. Upon exposure to ferroptosis-inducing compounds, ELAVL1 protein expression was remarkably increased through the inhibition of ... [more]
Autophagy Aug. 08, 2018; 14(12);2083-2103 [Pubmed: 30081711]
Throughput
- Low Throughput
Additional Notes
- when ELAVL1 protein is pulled down from cell lysates, BECN1 RNA is co-precipitated
Curated By
- BioGRID