SCN1B
Gene Ontology Biological Process
- axon guidance [ISO]
- cardiac conduction [ISO]
- cardiac muscle cell action potential involved in contraction [ISO]
- cardiac muscle contraction [ISO]
- corticospinal neuron axon guidance [ISO]
- locomotion [ISO]
- membrane depolarization [ISO]
- membrane depolarization during Purkinje myocyte cell action potential [ISO]
- membrane depolarization during cardiac muscle cell action potential [ISO]
- neuronal action potential propagation [ISO]
- positive regulation of neuron projection development [ISO]
- positive regulation of sodium ion transport [ISO]
- regulation of atrial cardiac muscle cell membrane depolarization [ISO]
- regulation of heart rate by cardiac conduction [ISO]
- regulation of sodium ion transmembrane transporter activity [ISO]
- regulation of sodium ion transport [IDA]
- regulation of ventricular cardiac muscle cell membrane repolarization [ISO]
- response to pyrethroid [IDA]
- sodium ion transmembrane transport [ISO]
Gene Ontology Molecular Function- protein binding [IPI]
- sodium channel inhibitor activity [ISO]
- sodium channel regulator activity [IDA, ISO]
- voltage-gated sodium channel activity [ISO]
- voltage-gated sodium channel activity involved in Purkinje myocyte action potential [ISO]
- voltage-gated sodium channel activity involved in cardiac muscle cell action potential [ISO]
- protein binding [IPI]
- sodium channel inhibitor activity [ISO]
- sodium channel regulator activity [IDA, ISO]
- voltage-gated sodium channel activity [ISO]
- voltage-gated sodium channel activity involved in Purkinje myocyte action potential [ISO]
- voltage-gated sodium channel activity involved in cardiac muscle cell action potential [ISO]
Gene Ontology Cellular Component
PTPRZ1
Gene Ontology Biological Process
- axonal fasciculation [IDA]
- axonogenesis [ISO]
- brain development [IEP]
- hematopoietic progenitor cell differentiation [ISO]
- hippocampus development [IEP]
- learning or memory [ISO, ISS]
- negative regulation of cell proliferation [IMP]
- negative regulation of cell-substrate adhesion [IDA]
- negative regulation of dendrite development [IDA]
- neuron development [IEP]
- oligodendrocyte differentiation [IEP, ISO, ISS]
- peptidyl-tyrosine dephosphorylation [IDA, ISO, ISS]
- positive regulation of Schwann cell migration [IMP]
- positive regulation of cell migration [IDA]
- positive regulation of dendrite development [IDA]
- positive regulation of fibroblast proliferation [IDA]
- positive regulation of neuron death [IDA]
- positive regulation of neuron migration [IMP]
- positive regulation of neuron projection development [IMP]
- positive regulation of peptidyl-tyrosine phosphorylation [IDA]
- protein dephosphorylation [IDA]
- regulation of dendrite morphogenesis [IMP]
- regulation of oligodendrocyte progenitor proliferation [ISO, ISS]
- visual learning [IEP]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Affinity Capture-Western
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner identified by Western blot with a specific polyclonal antibody or second epitope tag. This category is also used if an interacting protein is visualized directly by dye stain or radioactivity. Note that this differs from any co-purification experiment involving affinity capture in that the co-purification experiment involves at least one extra purification step to get rid of potential contaminating proteins.
Publication
A sodium channel signaling complex: modulation by associated receptor protein tyrosine phosphatase beta.
Voltage-gated sodium channels in brain neurons were found to associate with receptor protein tyrosine phosphatase beta (RPTPbeta) and its catalytically inactive, secreted isoform phosphacan, and this interaction was regulated during development. Both the extracellular domain and the intracellular catalytic domain of RPTPbeta interacted with sodium channels. Sodium channels were tyrosine phosphorylated and were modulated by the associated catalytic domains of ... [more]
Throughput
- Low Throughput
Curated By
- BioGRID