BAIT

AGR2

AG2, GOB-4, HAG-2, HEL-S-116, PDIA17, XAG-2, UNQ515/PRO1030
anterior gradient 2
GO Process (1)
GO Function (2)
GO Component (1)

Gene Ontology Biological Process

Gene Ontology Molecular Function

Gene Ontology Cellular Component

Homo sapiens
PREY

FSD1L

CCDC10, CSDUFD1, FSD1CL, FSD1NL, MIR1, RP11-235C23.3
fibronectin type III and SPRY domain containing 1-like
GO Process (0)
GO Function (0)
GO Component (0)
Homo sapiens

Affinity Capture-MS

An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods.

Publication

Loss of ER retention motif of AGR2 can impact mTORC signaling and promote cancer metastasis.

Tiemann K, Garri C, Lee SB, Malihi PD, Park M, Alvarez RM, Yap LP, Mallick P, Katz JE, Gross ME, Kani K

Anterior gradient 2 (AGR2) is a member of the protein disulfide isomerase (PDI) family, which plays a role in the regulation of protein homeostasis and the unfolded protein response pathway (UPR). AGR2 has also been characterized as a proto-oncogene and a potential cancer biomarker. Cellular localization of AGR2 is emerging as a key component for understanding the role of AGR2 ... [more]

Oncogene Dec. 21, 2018; (); [Pubmed: 30575818]

Throughput

  • High Throughput

Curated By

  • BioGRID