BAIT
AGR2
AG2, GOB-4, HAG-2, HEL-S-116, PDIA17, XAG-2, UNQ515/PRO1030
anterior gradient 2
GO Process (1)
GO Function (2)
GO Component (1)
Gene Ontology Biological Process
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
PREY
SPOCK1
SPOCK, TESTICAN, TIC1
sparc/osteonectin, cwcv and kazal-like domains proteoglycan (testican) 1
GO Process (9)
GO Function (4)
GO Component (6)
Gene Ontology Biological Process
- cell adhesion [NAS]
- central nervous system neuron differentiation [ISS]
- negative regulation of cell-substrate adhesion [IDA]
- negative regulation of endopeptidase activity [IDA]
- negative regulation of neuron projection development [IDA]
- nervous system development [NAS]
- neurogenesis [ISS]
- neuron migration [ISS]
- regulation of cell growth [NAS]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
Affinity Capture-MS
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods.
Publication
Loss of ER retention motif of AGR2 can impact mTORC signaling and promote cancer metastasis.
Anterior gradient 2 (AGR2) is a member of the protein disulfide isomerase (PDI) family, which plays a role in the regulation of protein homeostasis and the unfolded protein response pathway (UPR). AGR2 has also been characterized as a proto-oncogene and a potential cancer biomarker. Cellular localization of AGR2 is emerging as a key component for understanding the role of AGR2 ... [more]
Oncogene Dec. 21, 2018; (); [Pubmed: 30575818]
Throughput
- High Throughput
Curated By
- BioGRID