BAIT
PPP2R5D
B56D
protein phosphatase 2, regulatory subunit B', delta
GO Process (23)
GO Function (2)
GO Component (3)
Gene Ontology Biological Process
- MyD88-dependent toll-like receptor signaling pathway [TAS]
- MyD88-independent toll-like receptor signaling pathway [TAS]
- TRIF-dependent toll-like receptor signaling pathway [TAS]
- carbohydrate metabolic process [TAS]
- dephosphorylation [TAS]
- energy reserve metabolic process [TAS]
- glucose metabolic process [TAS]
- glycolytic process [TAS]
- innate immune response [TAS]
- nervous system development [TAS]
- neurotrophin TRK receptor signaling pathway [TAS]
- regulation of catalytic activity [TAS]
- small molecule metabolic process [TAS]
- stress-activated MAPK cascade [TAS]
- toll-like receptor 10 signaling pathway [TAS]
- toll-like receptor 2 signaling pathway [TAS]
- toll-like receptor 3 signaling pathway [TAS]
- toll-like receptor 4 signaling pathway [TAS]
- toll-like receptor 5 signaling pathway [TAS]
- toll-like receptor 9 signaling pathway [TAS]
- toll-like receptor TLR1:TLR2 signaling pathway [TAS]
- toll-like receptor TLR6:TLR2 signaling pathway [TAS]
- toll-like receptor signaling pathway [TAS]
Gene Ontology Molecular Function
Homo sapiens
PREY
HAND1
Hxt, Thing1, bHLHa27, eHand
heart and neural crest derivatives expressed 1
GO Process (16)
GO Function (10)
GO Component (3)
Gene Ontology Biological Process
- angiogenesis [ISS]
- blastocyst development [IEP]
- cardiac left ventricle formation [IMP]
- cardiac right ventricle formation [IMP]
- cardiac septum morphogenesis [IMP]
- embryonic heart tube development [ISS]
- heart development [ISS]
- heart looping [ISS]
- negative regulation of RNA polymerase II regulatory region sequence-specific DNA binding [IDA]
- negative regulation of sequence-specific DNA binding transcription factor activity [IDA]
- negative regulation of transcription from RNA polymerase II promoter [IDA]
- negative regulation of transcription, DNA-templated [IDA]
- positive regulation of transcription from RNA polymerase II promoter [IDA]
- transcription from RNA polymerase II promoter [IDA]
- trophectodermal cell differentiation [IEP]
- ventricular cardiac muscle tissue morphogenesis [IMP]
Gene Ontology Molecular Function- RNA polymerase II core promoter proximal region sequence-specific DNA binding [IDA]
- RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in negative regulation of transcription [IDA]
- bHLH transcription factor binding [IPI]
- identical protein binding [ISS]
- protein binding [IPI]
- protein homodimerization activity [NAS]
- transcription coactivator activity [IC, IDA]
- transcription corepressor activity [IC]
- transcription factor binding [IPI]
- transcription regulatory region DNA binding [IDA]
- RNA polymerase II core promoter proximal region sequence-specific DNA binding [IDA]
- RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in negative regulation of transcription [IDA]
- bHLH transcription factor binding [IPI]
- identical protein binding [ISS]
- protein binding [IPI]
- protein homodimerization activity [NAS]
- transcription coactivator activity [IC, IDA]
- transcription corepressor activity [IC]
- transcription factor binding [IPI]
- transcription regulatory region DNA binding [IDA]
Homo sapiens
Two-hybrid
Bait protein expressed as a DNA binding domain (DBD) fusion and prey expressed as a transcriptional activation domain (TAD) fusion and interaction measured by reporter gene activation.
Publication
PKA, PKC, and the protein phosphatase 2A influence HAND factor function: a mechanism for tissue-specific transcriptional regulation.
The bHLH factors HAND1 and HAND2 are required for heart, vascular, neuronal, limb, and extraembryonic development. Unlike most bHLH proteins, HAND factors exhibit promiscuous dimerization properties. We report that phosphorylation/dephosphorylation via PKA, PKC, and a specific heterotrimeric protein phosphatase 2A (PP2A) modulates HAND function. The PP2A targeting-subunit B56delta specifically interacts with HAND1 and -2, but not other bHLH proteins. PKA ... [more]
Mol. Cell Nov. 01, 2003; 12(5);1225-37 [Pubmed: 14636580]
Throughput
- Low Throughput
Curated By
- BioGRID