An interaction is inferred from the biochemical effect of one protein upon another, for example, GTP-GDP exchange activity or phosphorylation of a substrate by a kinase. The bait protein executes the activity on the substrate hit protein. A Modification value is recorded for interactions of this type with the possible values Phosphorylation, Ubiquitination, Sumoylation, Dephosphorylation, Methylation, Prenylation, Acetylation, Deubiquitination, Proteolytic Processing, Glucosylation, Nedd(Rub1)ylation, Deacetylation, No Modification, Demethylation.

Publication

RSK2 is required for TRAF6 phosphorylation-mediated colon inflammation.

Yao K, Lee SY, Peng C, Lim DY, Yamamoto H, Ryu J, Lim TG, Chen H, Jin G, Zhao Z, Han Y, Ma WY, Bode AM, Dong Z

Inflammation is a complex biological host reaction to tissue damage, infection and trauma. Extensive study of the inflammatory response has led to the identification of several protein kinases that are essential for signaling and could be potential therapeutic targets. The RSK family of kinases has multiple cellular functions. In our study, we found that RSK2 is a mediator for inflammation ... [more]

Oncogene Jun. 01, 2018; 37(26);3501-3513 [Pubmed: 29563609]

Throughput

Low Throughput

Additional Notes

autophosphorylation

Curated By

BioGRID

Interaction Summary

RPS6KA3

Gene Ontology Biological Process

Gene Ontology Molecular Function

cysteine-type endopeptidase inhibitor activity involved in apoptotic process [ISO]protein kinase binding [IPI]protein serine/threonine kinase activity [IDA]