BAIT
WWOX
D16S432E, FOR, FRA16D, HHCMA56, PRO0128, SCAR12, SDR41C1, WOX1
WW domain containing oxidoreductase
GO Process (7)
GO Function (7)
GO Component (8)
Gene Ontology Biological Process
- cellular response to transforming growth factor beta stimulus [IDA]
- negative regulation of Wnt signaling pathway [IDA]
- oxidation-reduction process [TAS]
- positive regulation of extrinsic apoptotic signaling pathway [ISS]
- positive regulation of transcription from RNA polymerase II promoter [ISS]
- skeletal system morphogenesis [ISS]
- steroid metabolic process [TAS]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
PREY
DNM1L
DLP1, DRP1, DVLP, DYMPLE, EMPF, HDYNIV
dynamin 1-like
GO Process (21)
GO Function (5)
GO Component (11)
Gene Ontology Biological Process
- GTP catabolic process [IDA]
- apoptotic process [TAS]
- cellular component disassembly involved in execution phase of apoptosis [TAS]
- dynamin polymerization involved in mitochondrial fission [IDA]
- membrane fission involved in mitochondrial fission [IDA]
- membrane fusion [IDA]
- mitochondrial fission [IDA, IMP]
- mitochondrial fragmentation involved in apoptotic process [IMP]
- mitochondrion morphogenesis [IMP]
- necroptotic process [IMP]
- peroxisome fission [IDA, IMP]
- positive regulation of apoptotic process [IMP]
- positive regulation of intrinsic apoptotic signaling pathway [IMP]
- positive regulation of mitochondrial fission [TAS]
- positive regulation of protein secretion [IDA]
- positive regulation of release of cytochrome c from mitochondria [IMP]
- protein homotetramerization [IDA]
- regulation of mitochondrion organization [IMP]
- regulation of peroxisome organization [IMP]
- regulation of protein oligomerization [IDA]
- release of cytochrome c from mitochondria [IMP]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
Affinity Capture-MS
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods.
Publication
Delineating WWOX Protein Interactome by Tandem Affinity Purification-Mass Spectrometry: Identification of Top Interactors and Key Metabolic Pathways Involved.
It has become clear from multiple studies that WWOX (WW domain-containing oxidoreductase) operates as a "non-classical" tumor suppressor of significant relevance in cancer progression. Additionally, WWOX has been recognized for its role in a much wider array of human pathologies including metabolic conditions and central nervous system related syndromes. A myriad of putative functional roles has been attributed to WWOX ... [more]
Front Oncol Jan. 09, 2019; 8();591 [Pubmed: 30619736]
Throughput
- High Throughput
Curated By
- BioGRID