SUFU
Gene Ontology Biological Process
- cytoplasmic sequestering of transcription factor [IGI]
- determination of left/right symmetry [IMP]
- heart looping [IMP]
- negative regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic process [IGI]
- negative regulation of smoothened signaling pathway [IDA, IMP]
- negative regulation of smoothened signaling pathway involved in dorsal/ventral neural tube patterning [IMP]
- negative regulation of transcription from RNA polymerase II promoter [IDA, ISO]
- neural tube closure [IMP]
- skin development [IMP]
- smoothened signaling pathway involved in spinal cord motor neuron cell fate specification [IMP]
- smoothened signaling pathway involved in ventral spinal cord interneuron specification [IMP]
- spinal cord dorsal/ventral patterning [IMP]
Gene Ontology Molecular Function
RNF19A
Gene Ontology Molecular Function
Two-hybrid
Bait protein expressed as a DNA binding domain (DBD) fusion and prey expressed as a transcriptional activation domain (TAD) fusion and interaction measured by reporter gene activation.
Publication
The negative regulator of Gli, Suppressor of fused (Sufu), interacts with SAP18, Galectin3 and other nuclear proteins.
Sufu (Suppressor of fused) is a negative regulator of the Hedgehog signal-transduction pathway, interacting directly with the Gli family of transcription factors. However, its function remains poorly understood. In the present study, we determined the expression, tissue distribution and biochemical properties of mSufu (mouse Sufu) protein. We identified several mSufu variants of which some were phosphorylated. A yeast two-hybrid screen ... [more]
Throughput
- Low Throughput
Related interactions
| Interaction | Experimental Evidence Code | Dataset | Throughput | Score | Curated By | Notes |
|---|---|---|---|---|---|---|
| RNF19A SUFU | Two-hybrid Two-hybrid Bait protein expressed as a DNA binding domain (DBD) fusion and prey expressed as a transcriptional activation domain (TAD) fusion and interaction measured by reporter gene activation. | Low | - | BioGRID | - |
Curated By
- BioGRID