BAIT
PIAS1
2900068C24Rik, Ddxbp1, GBP
protein inhibitor of activated STAT 1
GO Process (12)
GO Function (7)
GO Component (3)
Gene Ontology Biological Process
- JAK-STAT cascade [ISA]
- mitotic S phase [ISO]
- negative regulation of apoptotic process [ISO]
- negative regulation of nucleic acid-templated transcription [ISA]
- negative regulation of transcription from RNA polymerase II promoter [IMP]
- positive regulation of proteasomal ubiquitin-dependent protein catabolic process [IMP]
- positive regulation of protein sumoylation [ISO]
- positive regulation of smooth muscle cell differentiation [ISO]
- positive regulation of transcription, DNA-templated [ISO]
- protein sumoylation [IDA]
- protein-DNA complex assembly [ISO]
- regulation of cell proliferation [IMP]
Gene Ontology Molecular Function
Mus musculus
PREY
GLI3
ACLS, GCPS, GLI3-190, GLI3FL, PAP-A, PAPA, PAPA1, PAPB, PHS, PPDIV
GLI family zinc finger 3
GO Process (16)
GO Function (7)
GO Component (5)
Gene Ontology Biological Process
- T cell differentiation in thymus [ISS]
- embryonic digestive tract development [TAS]
- embryonic digit morphogenesis [TAS]
- limb morphogenesis [IMP]
- negative regulation of alpha-beta T cell differentiation [ISS]
- negative regulation of canonical Wnt signaling pathway [IDA]
- negative regulation of smoothened signaling pathway [ISS]
- negative regulation of transcription from RNA polymerase II promoter [IDA]
- negative regulation of transcription, DNA-templated [IDA]
- negative thymic T cell selection [ISS]
- nose morphogenesis [TAS]
- positive regulation of alpha-beta T cell differentiation [ISS]
- positive regulation of transcription from RNA polymerase II promoter [IDA, IMP]
- positive regulation of transcription, DNA-templated [ISS]
- smoothened signaling pathway [TAS]
- thymocyte apoptotic process [ISS]
Gene Ontology Molecular Function- RNA polymerase II core promoter proximal region sequence-specific DNA binding [IDA]
- RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription [IC]
- beta-catenin binding [IPI]
- histone acetyltransferase binding [IPI]
- histone deacetylase binding [IDA]
- protein binding [IPI]
- sequence-specific DNA binding transcription factor activity [IDA]
- RNA polymerase II core promoter proximal region sequence-specific DNA binding [IDA]
- RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription [IC]
- beta-catenin binding [IPI]
- histone acetyltransferase binding [IPI]
- histone deacetylase binding [IDA]
- protein binding [IPI]
- sequence-specific DNA binding transcription factor activity [IDA]
Homo sapiens
Two-hybrid
Bait protein expressed as a DNA binding domain (DBD) fusion and prey expressed as a transcriptional activation domain (TAD) fusion and interaction measured by reporter gene activation.
Publication
The negative regulator of Gli, Suppressor of fused (Sufu), interacts with SAP18, Galectin3 and other nuclear proteins.
Sufu (Suppressor of fused) is a negative regulator of the Hedgehog signal-transduction pathway, interacting directly with the Gli family of transcription factors. However, its function remains poorly understood. In the present study, we determined the expression, tissue distribution and biochemical properties of mSufu (mouse Sufu) protein. We identified several mSufu variants of which some were phosphorylated. A yeast two-hybrid screen ... [more]
Biochem. J. Mar. 01, 2004; 378(0);353-62 [Pubmed: 14611647]
Throughput
- Low Throughput
Curated By
- BioGRID