BAIT
RECQL4
RECQ4
RecQ protein-like 4
GO Process (5)
GO Function (4)
GO Component (1)
Gene Ontology Biological Process
Gene Ontology Molecular Function
Homo sapiens
PREY
GSTM2
GST4, GSTM, GSTM2-2, GTHMUS
glutathione S-transferase mu 2 (muscle)
GO Process (14)
GO Function (5)
GO Component (4)
Gene Ontology Biological Process
- cellular detoxification of nitrogen compound [IDA]
- cellular response to caffeine [IDA]
- glutathione derivative biosynthetic process [TAS]
- glutathione metabolic process [IDA]
- negative regulation of ryanodine-sensitive calcium-release channel activity [IDA]
- nitrobenzene metabolic process [IDA]
- positive regulation of ryanodine-sensitive calcium-release channel activity [IDA]
- regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion [IC]
- regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum [IDA]
- regulation of skeletal muscle contraction by regulation of release of sequestered calcium ion [IC]
- relaxation of cardiac muscle [TAS]
- small molecule metabolic process [TAS]
- xenobiotic catabolic process [IDA]
- xenobiotic metabolic process [TAS]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
Affinity Capture-MS
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods.
Publication
Cell cycle-dependent phosphorylation regulates RECQL4 pathway choice and ubiquitination in DNA double-strand break repair.
Pathway choice within DNA double-strand break (DSB) repair is a tightly regulated process to maintain genome integrity. RECQL4, deficient in Rothmund-Thomson Syndrome, promotes the two major DSB repair pathways, non-homologous end joining (NHEJ) and homologous recombination (HR). Here we report that RECQL4 promotes and coordinates NHEJ and HR in different cell cycle phases. RECQL4 interacts with Ku70 to promote NHEJ ... [more]
Nat Commun Dec. 11, 2016; 8(1);2039 [Pubmed: 29229926]
Throughput
- High Throughput
Curated By
- BioGRID