BAIT
ALDH1L1
10-FTHFDH, 10-fTHF, FDH, FTHFD
aldehyde dehydrogenase 1 family, member L1
GO Process (0)
GO Function (3)
GO Component (1)
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
PREY
USP47
TRFP
ubiquitin specific peptidase 47
GO Process (12)
GO Function (5)
GO Component (3)
Gene Ontology Biological Process
- base-excision repair [IMP]
- cellular response to DNA damage stimulus [IMP]
- cellular response to UV [ISS]
- monoubiquitinated protein deubiquitination [IDA]
- negative regulation of G2/M transition of mitotic cell cycle [IMP]
- negative regulation of apoptotic process [IMP]
- negative regulation of cysteine-type endopeptidase activity involved in apoptotic process [IMP]
- negative regulation of transcription, DNA-templated [IMP]
- positive regulation of cell growth [IMP]
- proteasome-mediated ubiquitin-dependent protein catabolic process [IBA]
- regulation of proteasomal protein catabolic process [IBA]
- response to drug [IMP]
Gene Ontology Molecular Function
Homo sapiens
Affinity Capture-MS
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods.
Publication
CHIP E3 ligase mediates proteasomal degradation of the proliferation regulatory protein ALDH1L1 during the transition of NIH3T3 fibroblasts from G0/G1 to S-phase.
ALDH1L1 is a folate-metabolizing enzyme abundant in liver and several other tissues. In human cancers and cell lines derived from malignant tumors, the ALDH1L1 gene is commonly silenced through the promoter methylation. It was suggested that ALDH1L1 limits proliferation capacity of the cell and thus functions as putative tumor suppressor. In contrast to cancer cells, mouse cell lines NIH3T3 and ... [more]
PLoS ONE Jul. 07, 2018; 13(7);e0199699 [Pubmed: 29979702]
Throughput
- High Throughput
Curated By
- BioGRID