FGF7
Gene Ontology Biological Process
- Fc-epsilon receptor signaling pathway [TAS]
- actin cytoskeleton reorganization [IDA]
- epidermal growth factor receptor signaling pathway [TAS]
- epidermis development [TAS]
- fibroblast growth factor receptor signaling pathway [IGI, TAS]
- innate immune response [TAS]
- insulin receptor signaling pathway [TAS]
- mesenchymal cell proliferation [IDA]
- neurotrophin TRK receptor signaling pathway [TAS]
- phosphatidylinositol-mediated signaling [TAS]
- positive chemotaxis [IDA]
- positive regulation of cell proliferation [IGI]
- positive regulation of epithelial cell proliferation [IDA]
- positive regulation of epithelial cell proliferation involved in lung morphogenesis [IDA]
- positive regulation of keratinocyte migration [IDA]
- positive regulation of keratinocyte proliferation [IDA]
- positive regulation of peptidyl-tyrosine phosphorylation [IDA]
- protein localization to cell surface [IDA]
- response to wounding [TAS]
- secretion by lung epithelial cell involved in lung growth [IDA]
- signal transduction [NAS]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
PTX3
Gene Ontology Biological Process
- inflammatory response [TAS]
- innate immune response [IDA]
- negative regulation by host of viral exo-alpha-sialidase activity [IDA]
- negative regulation by host of viral glycoprotein metabolic process [IDA]
- negative regulation of exo-alpha-sialidase activity [IDA]
- negative regulation of glycoprotein metabolic process [IDA]
- negative regulation of viral entry into host cell [IDA]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Reconstituted Complex
An interaction is inferred between proteins in vitro. This can include proteins in recombinant form or proteins isolated directly from cells with recombinant or purified bait. For example, GST pull-down assays where a GST-tagged protein is first isolated and then used to fish interactors from cell lysates are considered reconstituted complexes (e.g. PUBMED: 14657240, Fig. 4A or PUBMED: 14761940, Fig. 5). This can also include gel-shifts, surface plasmon resonance, isothermal titration calorimetry (ITC) and bio-layer interferometry (BLI) experiments. The bait-hit directionality may not be clear for 2 interacting proteins. In these cases the directionality is up to the discretion of the curator.
Publication
A long pentraxin-3-derived pentapeptide for the therapy of FGF8b-driven steroid hormone-regulated cancers.
Fibroblast growth factor-8b (FGF8b) affects the epithelial/stromal compartments of steroid hormone-regulated tumors by exerting an autocrine activity on cancer cells and a paracrine pro-angiogenic function, thus contributing to tumor progression. The FGF8b/FGF receptor (FGFR) system may therefore represent a target for the treatment of steroid hormone-regulated tumors. The soluble pattern recognition receptor long pentraxin-3 (PTX3) binds various FGFs, including FGF2 ... [more]
Throughput
- Low Throughput
Additional Notes
- SPR
Curated By
- BioGRID