SIRPA
Gene Ontology Biological Process
Gene Ontology Molecular Function
Gene Ontology Cellular Component
CD47
Gene Ontology Biological Process
- cell migration [ISO]
- opsonization [IDA]
- positive regulation of T cell activation [ISO]
- positive regulation of cell proliferation [ISO]
- positive regulation of cell-cell adhesion [ISO]
- positive regulation of inflammatory response [IMP]
- positive regulation of phagocytosis [IDA]
- response to bacterium [IMP]
- signal transduction [ISO]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Reconstituted Complex
An interaction is inferred between proteins in vitro. This can include proteins in recombinant form or proteins isolated directly from cells with recombinant or purified bait. For example, GST pull-down assays where a GST-tagged protein is first isolated and then used to fish interactors from cell lysates are considered reconstituted complexes (e.g. PUBMED: 14657240, Fig. 4A or PUBMED: 14761940, Fig. 5). This can also include gel-shifts, surface plasmon resonance, isothermal titration calorimetry (ITC) and bio-layer interferometry (BLI) experiments. The bait-hit directionality may not be clear for 2 interacting proteins. In these cases the directionality is up to the discretion of the curator.
Publication
Structural insight into the specific interaction between murine SHPS-1/SIRP alpha and its ligand CD47.
SRC homology 2 domain-containing protein tyrosine phosphatase substrate 1 (SHPS-1 or SIRP alpha/BIT) is an immunoglobulin (Ig) superfamily transmembrane receptor and a member of the signal regulatory protein (SIRP) family involved in cell-cell interaction. SHPS-1 binds to its ligand CD47 to relay an inhibitory signal for cellular responses, whereas SIRPbeta, an activating member of the same family, does not bind ... [more]
Throughput
- Low Throughput
Curated By
- BioGRID