HDAC7
Gene Ontology Biological Process
- B cell activation [TAS]
- B cell differentiation [TAS]
- cell-cell junction assembly [IMP]
- chromatin modification [TAS]
- histone deacetylation [TAS]
- inflammatory response [TAS]
- negative regulation of interleukin-2 production [ISO]
- negative regulation of neuron death [ISO]
- negative regulation of osteoblast differentiation [ISO]
- negative regulation of striated muscle tissue development [TAS]
- negative regulation of transcription from RNA polymerase II promoter [IDA]
- negative regulation of transcription, DNA-templated [IDA, TAS]
- nervous system development [TAS]
- positive regulation of cell migration involved in sprouting angiogenesis [ISO]
- vasculogenesis [IMP]
Gene Ontology Molecular Function- 14-3-3 protein binding [ISO]
- activating transcription factor binding [ISO]
- chromatin binding [IDA]
- histone deacetylase activity [TAS]
- protein binding [IPI]
- protein kinase C binding [ISO]
- protein kinase binding [ISO]
- repressing transcription factor binding [ISO]
- transcription corepressor activity [IDA]
- transcription factor binding [TAS]
- 14-3-3 protein binding [ISO]
- activating transcription factor binding [ISO]
- chromatin binding [IDA]
- histone deacetylase activity [TAS]
- protein binding [IPI]
- protein kinase C binding [ISO]
- protein kinase binding [ISO]
- repressing transcription factor binding [ISO]
- transcription corepressor activity [IDA]
- transcription factor binding [TAS]
CTBP1
Gene Ontology Biological Process
- Golgi organization [ISO]
- chromatin organization involved in regulation of transcription [ISO]
- negative regulation of histone H4 acetylation [ISO]
- negative regulation of histone acetylation [ISO]
- negative regulation of transcription from RNA polymerase II promoter [IMP, ISO]
- negative regulation of transcription, DNA-templated [IDA]
- positive regulation of histone deacetylation [ISO]
- regulation of cell cycle [ISO]
- transcription from RNA polymerase II promoter [ISO]
- white fat cell differentiation [IDA]
Gene Ontology Molecular Function- NAD binding [ISO]
- RNA polymerase II transcription corepressor activity [ISO]
- protein binding [IPI]
- protein domain specific binding [ISO]
- protein homodimerization activity [ISO]
- repressing transcription factor binding [ISO]
- sequence-specific DNA binding transcription factor activity [IDA]
- transcription factor binding [IPI, ISO]
- NAD binding [ISO]
- RNA polymerase II transcription corepressor activity [ISO]
- protein binding [IPI]
- protein domain specific binding [ISO]
- protein homodimerization activity [ISO]
- repressing transcription factor binding [ISO]
- sequence-specific DNA binding transcription factor activity [IDA]
- transcription factor binding [IPI, ISO]
Gene Ontology Cellular Component
Affinity Capture-Western
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner identified by Western blot with a specific polyclonal antibody or second epitope tag. This category is also used if an interacting protein is visualized directly by dye stain or radioactivity. Note that this differs from any co-purification experiment involving affinity capture in that the co-purification experiment involves at least one extra purification step to get rid of potential contaminating proteins.
Publication
Histone deacetylase 7 promotes Toll-like receptor 4-dependent proinflammatory gene expression in macrophages.
Broad-spectrum inhibitors of histone deacetylases (HDACs) constrain Toll-like receptor (TLR)-inducible production of key proinflammatory mediators. Here we investigated HDAC-dependent inflammatory responses in mouse macrophages. Of the classical Hdacs, Hdac7 was expressed at elevated levels in inflammatory macrophages (thioglycollate-elicited peritoneal macrophages) as compared with bone marrow-derived macrophages and the RAW264 cell line. Overexpression of a specific, alternatively spliced isoform of Hdac7 ... [more]
Throughput
- Low Throughput
Curated By
- BioGRID