An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods.

Publication

MARK4 is a novel microtubule-associated proteins/microtubule affinity-regulating kinase that binds to the cellular microtubule network and to centrosomes.

Trinczek B, Brajenovic M, Ebneth A, Drewes G

The MARK protein kinases were originally identified by their ability to phosphorylate a serine motif in the microtubule-binding domain of tau that is critical for microtubule binding. Here, we report the cloning and expression of a novel human paralog, MARK4, which shares 75% overall homology with MARK1-3 and is predominantly expressed in brain. Homology is most pronounced in the catalytic ... [more]

J. Biol. Chem. Feb. 13, 2004; 279(7);5915-23 [Pubmed: 14594945]

Throughput

Low Throughput

Curated By

BioGRID

Interaction Summary

MARK4

Gene Ontology Biological Process

Gene Ontology Molecular Function

ATP binding [NAS]gamma-tubulin binding [IDA]microtubule binding [IDA]protein binding [IPI]protein serine/threonine kinase activity [IDA]tau-protein kinase activity [IDA]ubiquitin binding [NAS]

Gene Ontology Cellular Component

HSPA4