VIM
Gene Ontology Biological Process
- Bergmann glial cell differentiation [IMP]
- SMAD protein signal transduction [IDA]
- astrocyte development [IGI]
- intermediate filament organization [IGI]
- intermediate filament-based process [IMP]
- lens fiber cell development [IDA]
- negative regulation of neuron projection development [IGI]
- positive regulation of gene expression [IMP]
- positive regulation of glial cell proliferation [ISO]
- regulation of Schwann cell migration [ISO]
- regulation of axonogenesis [ISO]
Gene Ontology Molecular Function- double-stranded RNA binding [ISO]
- glycoprotein binding [ISO]
- identical protein binding [ISO]
- kinase binding [ISO]
- protein C-terminus binding [ISO]
- protein binding [IPI]
- protein kinase binding [ISO]
- protein phosphatase 2A binding [ISO]
- scaffold protein binding [ISO]
- structural constituent of cytoskeleton [ISO]
- structural constituent of eye lens [IDA]
- structural molecule activity [IMP]
- double-stranded RNA binding [ISO]
- glycoprotein binding [ISO]
- identical protein binding [ISO]
- kinase binding [ISO]
- protein C-terminus binding [ISO]
- protein binding [IPI]
- protein kinase binding [ISO]
- protein phosphatase 2A binding [ISO]
- scaffold protein binding [ISO]
- structural constituent of cytoskeleton [ISO]
- structural constituent of eye lens [IDA]
- structural molecule activity [IMP]
Gene Ontology Cellular Component
- axon [ISO]
- cell body [ISO]
- cell leading edge [IDA]
- cell projection [IDA, ISO]
- cytoplasm [IDA, ISO]
- cytoskeleton [ISO]
- cytosol [ISO]
- extracellular vesicular exosome [ISO]
- focal adhesion [ISO]
- intermediate filament [IDA, ISO]
- intermediate filament cytoskeleton [ISO]
- neuron projection [IDA]
- perinuclear region of cytoplasm [ISO]
- peroxisome [ISO]
- plasma membrane [IDA, ISO]
- type III intermediate filament [TAS]
PTPRB
Gene Ontology Biological Process
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Affinity Capture-Western
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner identified by Western blot with a specific polyclonal antibody or second epitope tag. This category is also used if an interacting protein is visualized directly by dye stain or radioactivity. Note that this differs from any co-purification experiment involving affinity capture in that the co-purification experiment involves at least one extra purification step to get rid of potential contaminating proteins.
Publication
IRS-1 Functions as a Molecular Scaffold to Coordinate IGF-I/IGFBP-2 Signaling During Osteoblast Differentiation.
Insulin like growth factor I (IGF-I) and insulin like growth factor binding protein-2 (IGFBP-2) function coordinately to stimulate AKT and osteoblast differentiation. IGFBP-2 binding to receptor protein tyrosine phosphatase β (RPTPβ) stimulates polymerization and inactivation of phosphatase activity. Because phosphatase and tensin homolog (PTEN) is the primary target of RPTPβ, this leads to enhanced PTEN tyrosine phosphorylation and inactivation. However ... [more]
Throughput
- Low Throughput
Curated By
- BioGRID