VIM
Gene Ontology Biological Process
- Bergmann glial cell differentiation [IMP]
- SMAD protein signal transduction [IDA]
- astrocyte development [IGI]
- intermediate filament organization [IGI]
- intermediate filament-based process [IMP]
- lens fiber cell development [IDA]
- negative regulation of neuron projection development [IGI]
- positive regulation of gene expression [IMP]
- positive regulation of glial cell proliferation [ISO]
- regulation of Schwann cell migration [ISO]
- regulation of axonogenesis [ISO]
Gene Ontology Molecular Function- double-stranded RNA binding [ISO]
- glycoprotein binding [ISO]
- identical protein binding [ISO]
- kinase binding [ISO]
- protein C-terminus binding [ISO]
- protein binding [IPI]
- protein kinase binding [ISO]
- protein phosphatase 2A binding [ISO]
- scaffold protein binding [ISO]
- structural constituent of cytoskeleton [ISO]
- structural constituent of eye lens [IDA]
- structural molecule activity [IMP]
- double-stranded RNA binding [ISO]
- glycoprotein binding [ISO]
- identical protein binding [ISO]
- kinase binding [ISO]
- protein C-terminus binding [ISO]
- protein binding [IPI]
- protein kinase binding [ISO]
- protein phosphatase 2A binding [ISO]
- scaffold protein binding [ISO]
- structural constituent of cytoskeleton [ISO]
- structural constituent of eye lens [IDA]
- structural molecule activity [IMP]
Gene Ontology Cellular Component
- axon [ISO]
- cell body [ISO]
- cell leading edge [IDA]
- cell projection [IDA, ISO]
- cytoplasm [IDA, ISO]
- cytoskeleton [ISO]
- cytosol [ISO]
- extracellular vesicular exosome [ISO]
- focal adhesion [ISO]
- intermediate filament [IDA, ISO]
- intermediate filament cytoskeleton [ISO]
- neuron projection [IDA]
- perinuclear region of cytoplasm [ISO]
- peroxisome [ISO]
- plasma membrane [IDA, ISO]
- type III intermediate filament [TAS]
PRKCZ
Gene Ontology Biological Process
- actin cytoskeleton reorganization [ISO]
- activation of phospholipase D activity [ISO]
- activation of protein kinase B activity [ISO]
- cell migration [ISO]
- cell surface receptor signaling pathway [ISO]
- cellular protein localization [ISO]
- cellular response to insulin stimulus [ISO]
- establishment of cell polarity [ISO]
- insulin receptor signaling pathway [ISO]
- intracellular signal transduction [ISO]
- long-term memory [ISO]
- long-term synaptic potentiation [ISO]
- membrane depolarization [ISO]
- membrane hyperpolarization [ISO]
- microtubule cytoskeleton organization [IGI, IMP]
- negative regulation of apoptotic process [ISO]
- negative regulation of hydrolase activity [ISO]
- negative regulation of insulin receptor signaling pathway [ISO]
- negative regulation of peptidyl-tyrosine phosphorylation [ISO]
- negative regulation of protein complex assembly [ISO]
- neuron projection extension [IGI]
- peptidyl-serine phosphorylation [ISO]
- positive regulation of ERK1 and ERK2 cascade [ISO]
- positive regulation of NF-kappaB transcription factor activity [ISO]
- positive regulation of T-helper 2 cell cytokine production [IMP]
- positive regulation of T-helper 2 cell differentiation [IMP]
- positive regulation of cell proliferation [ISO]
- positive regulation of cell-matrix adhesion [ISO]
- positive regulation of excitatory postsynaptic membrane potential [ISO]
- positive regulation of glucose import [ISO]
- positive regulation of insulin receptor signaling pathway [ISO]
- positive regulation of interleukin-10 secretion [IMP]
- positive regulation of interleukin-13 secretion [IMP]
- positive regulation of interleukin-4 production [IMP]
- positive regulation of interleukin-5 secretion [IMP]
- positive regulation of protein transport [ISO]
- positive regulation of synaptic transmission [ISO]
- protein heterooligomerization [ISO]
- protein kinase C signaling [ISO]
- protein localization to plasma membrane [IMP]
- protein phosphorylation [IDA, ISO]
- signal transduction [ISO]
- vesicle transport along microtubule [ISO]
Gene Ontology Molecular Function- 14-3-3 protein binding [ISO]
- ATP binding [ISO]
- phospholipase binding [ISO]
- potassium channel regulator activity [ISO]
- protein binding [IPI]
- protein domain specific binding [ISO]
- protein kinase C activity [ISO]
- protein kinase activity [IDA, ISO]
- protein kinase binding [ISO]
- protein serine/threonine kinase activity [IDA, ISO]
- 14-3-3 protein binding [ISO]
- ATP binding [ISO]
- phospholipase binding [ISO]
- potassium channel regulator activity [ISO]
- protein binding [IPI]
- protein domain specific binding [ISO]
- protein kinase C activity [ISO]
- protein kinase activity [IDA, ISO]
- protein kinase binding [ISO]
- protein serine/threonine kinase activity [IDA, ISO]
Gene Ontology Cellular Component
- apical cortex [IDA]
- apical plasma membrane [IDA]
- axon hillock [IDA]
- cell cortex [IDA]
- cell leading edge [ISO]
- cell-cell junction [ISO]
- cytoplasm [IDA, ISO]
- cytosol [ISO]
- extracellular vesicular exosome [ISO]
- filamentous actin [ISO]
- intracellular membrane-bounded organelle [ISO]
- membrane raft [ISO]
- microtubule organizing center [IGI]
- myelin sheath abaxonal region [IDA]
- nuclear envelope [IDA]
- nuclear matrix [IDA]
- nucleus [IDA]
- perinuclear region of cytoplasm [ISO]
- plasma membrane [IDA, ISO]
- protein complex [IDA, ISO]
- tight junction [IDA]
Affinity Capture-Western
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner identified by Western blot with a specific polyclonal antibody or second epitope tag. This category is also used if an interacting protein is visualized directly by dye stain or radioactivity. Note that this differs from any co-purification experiment involving affinity capture in that the co-purification experiment involves at least one extra purification step to get rid of potential contaminating proteins.
Publication
IRS-1 Functions as a Molecular Scaffold to Coordinate IGF-I/IGFBP-2 Signaling During Osteoblast Differentiation.
Insulin like growth factor I (IGF-I) and insulin like growth factor binding protein-2 (IGFBP-2) function coordinately to stimulate AKT and osteoblast differentiation. IGFBP-2 binding to receptor protein tyrosine phosphatase β (RPTPβ) stimulates polymerization and inactivation of phosphatase activity. Because phosphatase and tensin homolog (PTEN) is the primary target of RPTPβ, this leads to enhanced PTEN tyrosine phosphorylation and inactivation. However ... [more]
Throughput
- Low Throughput
Related interactions
| Interaction | Experimental Evidence Code | Dataset | Throughput | Score | Curated By | Notes |
|---|---|---|---|---|---|---|
| PRKCZ VIM | Biochemical Activity Biochemical Activity An interaction is inferred from the biochemical effect of one protein upon another, for example, GTP-GDP exchange activity or phosphorylation of a substrate by a kinase. The bait protein executes the activity on the substrate hit protein. A Modification value is recorded for interactions of this type with the possible values Phosphorylation, Ubiquitination, Sumoylation, Dephosphorylation, Methylation, Prenylation, Acetylation, Deubiquitination, Proteolytic Processing, Glucosylation, Nedd(Rub1)ylation, Deacetylation, No Modification, Demethylation. | Low | - | BioGRID | 2532857 |
Curated By
- BioGRID