IRS1
Gene Ontology Biological Process
- cellular response to insulin stimulus [IDA, ISO]
- insulin receptor signaling pathway [IBA, ISO]
- insulin secretion [IMP]
- insulin-like growth factor receptor signaling pathway [ISO]
- lipid catabolic process [IMP]
- mammary gland development [IGI]
- negative regulation of insulin receptor signaling pathway [ISO]
- negative regulation of insulin secretion [ISO]
- negative regulation of somatostatin secretion [ISO]
- phosphatidylinositol 3-kinase signaling [ISO]
- positive regulation of cell migration [IGI]
- positive regulation of fatty acid beta-oxidation [ISO]
- positive regulation of glucagon secretion [ISO]
- positive regulation of glucose import [ISO]
- positive regulation of glucose import in response to insulin stimulus [ISO]
- positive regulation of glucose metabolic process [ISO]
- positive regulation of glycogen biosynthetic process [ISO]
- positive regulation of insulin receptor signaling pathway [ISO]
- positive regulation of mesenchymal cell proliferation [IGI]
- positive regulation of phosphatidylinositol 3-kinase activity [IMP, ISO]
- positive regulation of phosphorylation [ISO]
- protein heterooligomerization [ISO]
- protein kinase B signaling [IGI]
- protein localization to nucleus [IDA, IMP]
- regulation of gene expression [IMP]
- response to caffeine [ISO]
- response to insulin [ISO]
- response to peptide hormone [ISO]
Gene Ontology Molecular Function- SH2 domain binding [ISO]
- insulin receptor binding [IBA, ISO]
- insulin-like growth factor receptor binding [ISO]
- phosphatidylinositol 3-kinase binding [IDA, ISO]
- protein binding [IPI]
- protein domain specific binding [ISO]
- protein kinase C binding [ISO]
- protein kinase binding [IDA, ISO]
- signal transducer activity [IBA]
- transmembrane receptor protein tyrosine kinase adaptor activity [ISO]
- SH2 domain binding [ISO]
- insulin receptor binding [IBA, ISO]
- insulin-like growth factor receptor binding [ISO]
- phosphatidylinositol 3-kinase binding [IDA, ISO]
- protein binding [IPI]
- protein domain specific binding [ISO]
- protein kinase C binding [ISO]
- protein kinase binding [IDA, ISO]
- signal transducer activity [IBA]
- transmembrane receptor protein tyrosine kinase adaptor activity [ISO]
Gene Ontology Cellular Component
SQSTM1
Gene Ontology Biological Process
- autophagy [ISO]
- positive regulation of macroautophagy [IBA, ISO]
- positive regulation of protein phosphorylation [ISO]
- protein heterooligomerization [ISO]
- regulation of I-kappaB kinase/NF-kappaB signaling [ISO]
- regulation of nucleic acid-templated transcription [TAS]
- ubiquitin-dependent protein catabolic process [IBA]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Affinity Capture-Western
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner identified by Western blot with a specific polyclonal antibody or second epitope tag. This category is also used if an interacting protein is visualized directly by dye stain or radioactivity. Note that this differs from any co-purification experiment involving affinity capture in that the co-purification experiment involves at least one extra purification step to get rid of potential contaminating proteins.
Publication
IRS-1 Functions as a Molecular Scaffold to Coordinate IGF-I/IGFBP-2 Signaling During Osteoblast Differentiation.
Insulin like growth factor I (IGF-I) and insulin like growth factor binding protein-2 (IGFBP-2) function coordinately to stimulate AKT and osteoblast differentiation. IGFBP-2 binding to receptor protein tyrosine phosphatase β (RPTPβ) stimulates polymerization and inactivation of phosphatase activity. Because phosphatase and tensin homolog (PTEN) is the primary target of RPTPβ, this leads to enhanced PTEN tyrosine phosphorylation and inactivation. However ... [more]
Throughput
- Low Throughput
Curated By
- BioGRID