ITGA3
Gene Ontology Biological Process
- cell adhesion [ISO]
- dendritic spine maintenance [IGI, IMP]
- exploration behavior [IGI]
- fusion of sperm to egg plasma membrane [IMP]
- lung development [ISO]
- memory [IMP]
- negative regulation of Rho protein signal transduction [IGI]
- negative regulation of cell projection organization [ISO]
- nephron development [ISO]
- neuron migration [IMP]
- positive regulation of cell-substrate adhesion [ISO]
- positive regulation of epithelial cell migration [ISO]
- positive regulation of establishment of protein localization to plasma membrane [ISO]
- positive regulation of gene expression [ISO]
- positive regulation of neuron projection development [ISO]
- regulation of BMP signaling pathway [ISO]
- regulation of Wnt signaling pathway [ISO]
- regulation of transforming growth factor beta receptor signaling pathway [ISO]
- renal filtration [ISO]
- single-organism behavior [IMP]
- skin development [ISO]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
- basolateral plasma membrane [IDA]
- cell periphery [ISO]
- cell surface [ISO]
- excitatory synapse [IDA]
- external side of plasma membrane [IDA]
- extracellular vesicular exosome [ISO]
- filopodium membrane [ISO]
- focal adhesion [ISO]
- growth cone [ISO]
- integrin alpha3-beta1 complex [ISO]
- invadopodium membrane [ISO]
- perinuclear region of cytoplasm [ISO]
- plasma membrane [IDA, ISO]
- receptor complex [ISO]
- synapse [IDA]
- synaptic membrane [IDA]
SDC4
Gene Ontology Biological Process
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Affinity Capture-Western
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner identified by Western blot with a specific polyclonal antibody or second epitope tag. This category is also used if an interacting protein is visualized directly by dye stain or radioactivity. Note that this differs from any co-purification experiment involving affinity capture in that the co-purification experiment involves at least one extra purification step to get rid of potential contaminating proteins.
Publication
Cytoplasmic domain interactions of syndecan-1 and syndecan-4 with α6β4 integrin mediate human epidermal growth factor receptor (HER1 and HER2)-dependent motility and survival.
Epithelial cells are highly dependent during wound healing and tumorigenesis on the α6β4 integrin and its association with receptor tyrosine kinases. Previous work showed that phosphorylation of the β4 subunit upon matrix engagement depends on the matrix receptor syndecan (Sdc)-1 engaging the cytoplasmic domain of the β4 integrin and coupling of the integrin to human epidermal growth factor receptor-2 (HER2). ... [more]
Throughput
- Low Throughput
Curated By
- BioGRID