BAIT
E2F6
E2F-6
E2F transcription factor 6
GO Process (1)
GO Function (1)
GO Component (2)
Gene Ontology Biological Process
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
PREY
ZBTB17
MIZ-1, ZNF151, ZNF60, pHZ-67, RP1-134O19.2
zinc finger and BTB domain containing 17
GO Process (4)
GO Function (2)
GO Component (1)
Gene Ontology Biological Process
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
Two-hybrid
Bait protein expressed as a DNA binding domain (DBD) fusion and prey expressed as a transcriptional activation domain (TAD) fusion and interaction measured by reporter gene activation.
Publication
E2F6 associates with BRG1 in transcriptional regulation.
The E2F6 protein functions as an Rb-independent repressor of gene transcription. We have previously provided evidence suggesting a role for E2F6 in repression of E2F-responsive genes at S phase. Here, we have identified BRG1, the ATPase subunit of the SWI/SNF chromatin-remodeling complex, as an E2F6 interacting protein. Immunoprecipitation experiments demonstrate that BRG1 binds specifically to E2F6 and E2F4 but not ... [more]
PLoS ONE Oct. 20, 2012; 7(10);e47967 [Pubmed: 23082233]
Throughput
- Low Throughput
Curated By
- BioGRID