CNTNAP1
Gene Ontology Biological Process
- axon cargo transport [ISS]
- axon guidance [TAS]
- cytoskeleton organization [ISS]
- neuron projection morphogenesis [ISS]
- neuronal action potential propagation [ISS]
- paranodal junction assembly [ISS]
- positive regulation of signal transduction [TAS]
- protein localization to paranode region of axon [ISS]
- signal transduction [TAS]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
KCNA2
Gene Ontology Biological Process
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Affinity Capture-Western
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner identified by Western blot with a specific polyclonal antibody or second epitope tag. This category is also used if an interacting protein is visualized directly by dye stain or radioactivity. Note that this differs from any co-purification experiment involving affinity capture in that the co-purification experiment involves at least one extra purification step to get rid of potential contaminating proteins.
Publication
Nogo-A at CNS paranodes is a ligand of Caspr: possible regulation of K(+) channel localization.
We report Nogo-A as an oligodendroglial component congregating and interacting with the Caspr-F3 complex at paranodes. However, its receptor Nogo-66 receptor (NgR) does not segregate to specific axonal domains. CHO cells cotransfected with Caspr and F3, but not with F3 alone, bound specifically to substrates coated with Nogo-66 peptide and GST-Nogo-66. Binding persisted even after phosphatidylinositol- specific phospholipase C (PI-PLC) ... [more]
Throughput
- Low Throughput
Curated By
- BioGRID