BAIT
STUB1
CHIP, HSPABP2, NY-CO-7, SCAR16, SDCCAG7, UBOX1, LA16c-313D11.6
STIP1 homology and U-box containing protein 1, E3 ubiquitin protein ligase
GO Process (15)
GO Function (15)
GO Component (10)
Gene Ontology Biological Process
- cellular response to misfolded protein [IDA]
- misfolded or incompletely synthesized protein catabolic process [IDA]
- negative regulation of transforming growth factor beta receptor signaling pathway [TAS]
- positive regulation of chaperone-mediated protein complex assembly [IDA]
- positive regulation of proteasomal ubiquitin-dependent protein catabolic process [IDA]
- positive regulation of protein ubiquitination [IDA]
- proteasome-mediated ubiquitin-dependent protein catabolic process [IDA]
- protein K63-linked ubiquitination [IDA]
- protein autoubiquitination [IDA]
- protein maturation [TAS]
- protein polyubiquitination [IDA, IMP]
- regulation of glucocorticoid metabolic process [IDA]
- transforming growth factor beta receptor signaling pathway [TAS]
- ubiquitin-dependent SMAD protein catabolic process [IDA]
- ubiquitin-dependent protein catabolic process [IMP]
Gene Ontology Molecular Function- G-protein coupled receptor binding [IPI]
- Hsp70 protein binding [IDA]
- Hsp90 protein binding [IDA]
- SMAD binding [IDA]
- TPR domain binding [IDA]
- enzyme binding [IPI]
- kinase binding [IPI]
- misfolded protein binding [IDA]
- protein binding [IPI]
- protein binding, bridging [TAS]
- protein homodimerization activity [ISS]
- ubiquitin protein ligase activity [IDA]
- ubiquitin protein ligase binding [IPI]
- ubiquitin-protein transferase activity [IDA, IMP, TAS]
- ubiquitin-ubiquitin ligase activity [ISS]
- G-protein coupled receptor binding [IPI]
- Hsp70 protein binding [IDA]
- Hsp90 protein binding [IDA]
- SMAD binding [IDA]
- TPR domain binding [IDA]
- enzyme binding [IPI]
- kinase binding [IPI]
- misfolded protein binding [IDA]
- protein binding [IPI]
- protein binding, bridging [TAS]
- protein homodimerization activity [ISS]
- ubiquitin protein ligase activity [IDA]
- ubiquitin protein ligase binding [IPI]
- ubiquitin-protein transferase activity [IDA, IMP, TAS]
- ubiquitin-ubiquitin ligase activity [ISS]
Gene Ontology Cellular Component
Homo sapiens
PREY
CAD
carbamoyl-phosphate synthetase 2, aspartate transcarbamylase, and dihydroorotase
GO Process (11)
GO Function (10)
GO Component (10)
Gene Ontology Biological Process
- 'de novo' pyrimidine nucleobase biosynthetic process [IDA, ISS]
- arginine biosynthetic process [IBA]
- drug metabolic process [ISS]
- glutamine metabolic process [ISS]
- nucleobase-containing small molecule metabolic process [TAS]
- peptidyl-threonine phosphorylation [ISS]
- protein autophosphorylation [ISS]
- pyrimidine nucleobase metabolic process [TAS]
- pyrimidine nucleoside biosynthetic process [TAS]
- small molecule metabolic process [TAS]
- urea cycle [IBA]
Gene Ontology Molecular Function- ATP binding [ISS]
- aspartate binding [ISS]
- aspartate carbamoyltransferase activity [IBA, ISS, TAS]
- carbamoyl-phosphate synthase (ammonia) activity [IBA]
- carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity [IBA, ISS, TAS]
- dihydroorotase activity [IDA, ISS, TAS]
- enzyme binding [IPI]
- identical protein binding [ISS]
- protein kinase activity [ISS]
- zinc ion binding [IDA]
- ATP binding [ISS]
- aspartate binding [ISS]
- aspartate carbamoyltransferase activity [IBA, ISS, TAS]
- carbamoyl-phosphate synthase (ammonia) activity [IBA]
- carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity [IBA, ISS, TAS]
- dihydroorotase activity [IDA, ISS, TAS]
- enzyme binding [IPI]
- identical protein binding [ISS]
- protein kinase activity [ISS]
- zinc ion binding [IDA]
Gene Ontology Cellular Component
Homo sapiens
Affinity Capture-MS
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods.
Publication
Post-translational modification of OCT4 in breast cancer tumorigenesis.
Recurrence and drug resistance of breast cancer are still the main reasons for breast cancer-associated deaths. Cancer stem cell (CSC) model has been proposed as a hypothesis for the lethality of breast cancer. Molecular mechanisms underlying CSC maintenance are still unclear. In this study, we generated mammospheres derived from breast cancer MDA-MB231 cells and MCF7 cells to enrich CSCs and ... [more]
Cell Death Differ. Nov. 01, 2018; 25(10);1781-1795 [Pubmed: 29511337]
Throughput
- High Throughput
Curated By
- BioGRID