TAF9
Gene Ontology Biological Process
- cellular response to DNA damage stimulus [IC]
- chromatin organization [TAS]
- gene expression [TAS]
- histone H3 acetylation [IDA]
- negative regulation of apoptotic process [IMP]
- negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator [IC]
- negative regulation of proteasomal ubiquitin-dependent protein catabolic process [IDA]
- positive regulation of cell growth [IMP]
- positive regulation of response to cytokine stimulus [IMP]
- positive regulation of transcription from RNA polymerase II promoter [IDA]
- protein stabilization [IDA]
- response to interleukin-1 [IMP]
- transcription elongation from RNA polymerase II promoter [TAS]
- transcription from RNA polymerase II promoter [TAS]
- transcription initiation from RNA polymerase II promoter [TAS]
- viral process [TAS]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
GLI2
Gene Ontology Biological Process
- axon guidance [ISS]
- branching morphogenesis of an epithelial tube [ISS]
- cell proliferation [IDA]
- cellular response to virus [IDA]
- cerebellar cortex morphogenesis [ISS]
- developmental growth [ISS]
- embryonic digestive tract development [ISS]
- epidermal cell differentiation [IDA]
- floor plate formation [ISS]
- heart development [ISS]
- hindbrain development [ISS]
- hindgut morphogenesis [ISS]
- kidney development [ISS]
- lung development [ISS]
- mammary gland development [ISS]
- negative regulation of transcription from RNA polymerase II promoter [IDA, IMP]
- neuron development [ISS]
- odontogenesis of dentin-containing tooth [ISS]
- osteoblast development [ISS]
- osteoblast differentiation [IDA]
- pattern specification process [ISS]
- pituitary gland development [ISS]
- positive regulation of DNA replication [IDA]
- positive regulation of T cell differentiation in thymus [ISS]
- positive regulation of transcription from RNA polymerase II promoter [IDA]
- positive regulation of transcription, DNA-templated [IDA]
- proximal/distal pattern formation [ISS]
- skeletal system development [ISS]
- smoothened signaling pathway [IDA]
- smoothened signaling pathway involved in ventral spinal cord interneuron specification [ISS]
- spinal cord dorsal/ventral patterning [ISS]
- spinal cord ventral commissure morphogenesis [ISS]
- tube development [ISS]
- ventral midline development [ISS]
- ventral spinal cord development [ISS]
Gene Ontology Molecular Function
Reconstituted Complex
An interaction is inferred between proteins in vitro. This can include proteins in recombinant form or proteins isolated directly from cells with recombinant or purified bait. For example, GST pull-down assays where a GST-tagged protein is first isolated and then used to fish interactors from cell lysates are considered reconstituted complexes (e.g. PUBMED: 14657240, Fig. 4A or PUBMED: 14761940, Fig. 5). This can also include gel-shifts, surface plasmon resonance, isothermal titration calorimetry (ITC) and bio-layer interferometry (BLI) experiments. The bait-hit directionality may not be clear for 2 interacting proteins. In these cases the directionality is up to the discretion of the curator.
Publication
p53 modulates the activity of the GLI1 oncogene through interactions with the shared coactivator TAF9.
The GLI1 oncogene and p53 tumor suppressor gene function in an inhibitory loop that controls stem cell and tumor cell numbers. Since GLI1 and p53 both interact with the coactivator TATA Binding Protein Associated Factor 9 (TAF9), we hypothesized that competition between these transcription factors for TAF9 in cancer cells may contribute to the inhibitory loop and directly affect GLI1 ... [more]
Throughput
- Low Throughput
Curated By
- BioGRID