CSNK2A2
Gene Ontology Biological Process
Gene Ontology Molecular Function
TP63
Gene Ontology Biological Process
- DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator [IBA]
- apoptotic process [TAS]
- cellular response to DNA damage stimulus [IDA]
- cellular response to UV [IBA]
- establishment of skin barrier [ISS]
- intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator [IBA]
- mitotic G1 DNA damage checkpoint [IBA]
- negative regulation of cellular senescence [IMP]
- negative regulation of transcription from RNA polymerase II promoter [IBA]
- negative regulation of transcription, DNA-templated [IDA]
- positive regulation of Notch signaling pathway [IDA]
- positive regulation of cell cycle G1/S phase transition [IMP]
- positive regulation of fibroblast apoptotic process [IDA]
- positive regulation of osteoblast differentiation [IMP]
- positive regulation of transcription from RNA polymerase II promoter [IDA]
- positive regulation of transcription, DNA-templated [IDA, NAS]
- protein homotetramerization [IPI]
- regulation of epidermal cell division [ISS]
- regulation of neuron apoptotic process [IBA]
- response to X-ray [IBA]
- response to gamma radiation [IBA]
Gene Ontology Molecular Function
Biochemical Activity (Phosphorylation)
An interaction is inferred from the biochemical effect of one protein upon another, for example, GTP-GDP exchange activity or phosphorylation of a substrate by a kinase. The bait protein executes the activity on the substrate hit protein. A Modification value is recorded for interactions of this type with the possible values Phosphorylation, Ubiquitination, Sumoylation, Dephosphorylation, Methylation, Prenylation, Acetylation, Deubiquitination, Proteolytic Processing, Glucosylation, Nedd(Rub1)ylation, Deacetylation, No Modification, Demethylation.
Publication
p53 serine 392 phosphorylation increases after UV through induction of the assembly of the CK2.hSPT16.SSRP1 complex.
Previously, we purified a UV-responsive p53 serine 392 kinase from F9 and HeLa cells and found that its activity is attributed to a high molecular weight protein complex containing the protein kinase CK2, along with the chromatin-associated factors hSPT16 and SSRP1. Here we determine that these proteins interact in vitro and in cells via non-overlapping domains and provide evidence consistent ... [more]
Throughput
- Low Throughput
Curated By
- BioGRID