A genetic interaction is inferred when over expression or increased dosage of one gene rescues the lethality or growth defect of a strain that is mutated or deleted for another gene.

Publication

Msc6p is required for mitochondrial translation initiation in the absence of formylated Met-tRNAfmet.

Franco LVR, Moda BS, Soares MAKM, Barros MH

Mitochondrial translation normally requires formylation of the initiator tRNA-met, a reaction catalyzed by the enzyme formyl transferase, Fmt1p and MTFMT in Saccharomyces cerevisiae and human mitochondria, respectively. Yeast fmt1 mutants devoid of Fmt1p, however, can synthesize all mitochondrial gene products by initiating translation with a non-formylated methionyl tRNA. Yeast synthetic respiratory-deficient fmt1 mutants have uncovered several factors suggested to play ... [more]

FEBS J. Feb. 15, 2019; (); [Pubmed: 30767393]

Throughput

Low Throughput

Ontology Terms

vegetative growth (APO:0000106)

Additional Notes

genetic complex
overexpression of IFM1 partially rescues fmt1/msc6 growth defects

Related interactions

Interaction	Experimental Evidence Code	Dataset	Throughput	Score	Curated By	Notes
FMT1 IFM1	Negative Genetic Negative Genetic Mutations/deletions in separate genes, each of which alone causes a minimal phenotype, but when combined in the same cell results in a more severe fitness defect or lethality under a given condition. This term is reserved for high or low throughput studies with scores.	Wilmes GM (2008)	High	-3.1535	BioGRID	309836

Curated By

BioGRID

Interaction Summary

FMT1

Gene Ontology Biological Process

Gene Ontology Molecular Function

methionyl-tRNA formyltransferase activity [IDA, IMP]

Gene Ontology Cellular Component

IFM1